Abstract
Depression and apathy are among the most common neuropsychiatric disturbances in Parkinson's
disease (PD), and among the most important factors associated with a poor quality
of life. However, their neural bases remain unclear. The results of the magnetic resonance
imaging (MRI) studies on depression in PD differ dramatically. Some of them proposed
a role of morphologic changes in the mediodorsal thalamus. In contrast to previous
voxel-based morphometry (VBM) data, our study did not confirm a decrease in gray matter
(GM) density in any brain region of depressed PD patients. Instead, a more severe
white matter (WM) loss in the right frontal lobe was found, including the anterior
cingulate bundle and the inferior orbitofrontal (OF) region. We suggested that the
negative correlation between the severity of depression and WM density in the right
OF region reinforces the hypothesis of depression in PD as a “disconnection syndrome”.
Only one MRI study using VBM found that high apathy scores correlated with low GM
density values in the right (posterior) cingulate gyrus and the bilateral inferior
frontal gyrus, in line with the findings in Alzheimer's disease and elderly adults
with major depression.
Keywords
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References
- A systematic review of prevalence studies of depression in Parkinson's disease.Mov Disord. 2008; 23: 183-189
- Depression and Parkinson's disease: a review.Am J Psychiatry. 1992; 149: 443-454
- The syndromal validity and nosological position of apathy in Parkinson's disease.Mov Disord. 2009; 24: 1211-1216
- Apathy in drug-naïve patients with incident Parkinson's disease: the Norwegian ParkWest study.J Neurol. 2010; 257: 217-223
- Dissociating apathy and depression in Parkinson's disease.Neurology. 2006; 67: 33-38
- Imaging non-motor aspects of Parkinson's disease.in: Progress in Brain Research. vol 184. Elsevier BV, Amsterdam2010: 205-218
- Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease.Ann Neurol. 1990; 28: 57-64
- Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system.Brain. 2005; 128: 1314-1322
- Depressive symptoms in Parkinson's disease correlate with higher 5HTT binding in raphe and limbic structures.Neurology. 2010; 75: 1920-1927
- rTMS treatment for depression in Parkinson's disease increases BOLD responses in the left prefrontal cortex.Int J Neuropsychopharmacol. 2008; 11: 173-183
- Depression in Parkinson's disease: convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus.Neuroimage. 2009; 47: 467-472
- White matter microstructure changes in the thalamus in Parkinson disease with depression: a diffusion tensor MR imaging study.Am J Neuroradiol. 2010; 31: 1861-1866
- Morphometric changes of gray matter in Parkinson's disease with depression: a voxel-based morphometry study.Mov Disord. 2008; 23: 42-46
- Regional pattern of brain tisuue loss associated with depression in Parkinson disease.Neurology. 2010; 75: 857-863
- Depression in Parkinson's disease Diffusion tensor imaging study.J Neurol. 2007; 254: 1170-1173
- Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment.Br Med Bull. 2003; 65: 193-207
- Depression in Parkinson's disease: a biochemical and organic viewpoint.Adv Neurol. 1995; 65: 49-60
- Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits.Cereb Cortex. 2006; 16: 916-928
- Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson's disease.Mov Disord. 2002; 17: 366-371
- Neuroanatomical correlates of apathy in Parkinson's disease: a magnetic resonance imaging study using voxel-based morphometry.Mov Disord. 2010; 25: 2318-2325
- Subthalamic nucleus stimulation in Parkinson disease induces apathy: a PET study.Neurology. 2009; 73: 1746-1751
- Structural correlates of apathy in Alzheimer's disease.Dement Geriatr Cogn Disord. 2007; 24: 91-97
- Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation.Brain. 2010; 133: 1111-1127
Article info
Publication history
Published online: June 20, 2011
Accepted:
May 23,
2011
Received in revised form:
May 1,
2011
Received:
March 19,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
