Abstract
The term health-related quality of life (HRQoL) refers to the consequences of the
disease and treatment on the patients' life, as perceived and evaluated by patients
themselves. Parkinson's disease is a complex disorder characterized by motor manifestations
and an impressive diversity of non-motor symptoms (NMS) that may be simultaneously
present in the same patient. Some of these non-motor symptoms (for example, depression,
fatigue, or pain) have got evidence enough to be considered determinant factors of
HRQoL. For others, evidence is incomplete or results of the studies are inconsistent.
The availability of instruments for assessment of a wide set of NMS allows to evaluate
the impact of NMS, as a whole and compared to the motor disorder, on the HRQoL. In
that scenario, the whole NMS showed a close association with the quality of life deterioration,
exceeding even the effects of the motor disorder.
Keywords
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References
- Handbook of basic documents. 5th ed. WHO, Palais des Nations, Geneva1952: 3-20
- An introduction to the concept of “quality of life in Parkinson's disease”.J Neurol. 1998; 245: S2-S5
- Parkinson's disease.Lancet. 2009; 373: 2055-2066
- Non-motor symptoms of Parkinson's disease: diagnosis and management.Lancet Neurol. 2006; 5: 235-245
- Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients.Mov Disord. 2007; 22: 1623-1629
- International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease.Neurology. 2009; 73: 1584-1591
- Non-motor symptoms and health-related quality of life.in: Chaudhuri K.R. Tolosa E. Schapira A. Poewe W. Non-Motor Symptoms of Parkinson's Disease. Oxford University Press, Oxford2009: 309-320
- Impact of the non-motor disorder on the quality of life of patients with Parkinson's disease.in: Martínez-Martín P. Sánchez Andrés J.V. Non-motor Disorders in Parkinson's Disease. Viguera Editores, SL, Barcelona2009: 227-245 (Spanish)
- The current state of the art concerning quality of life in Parkinson's disease: II. Determinants and associated factors.Rev Neurol. 2009; 49 (Spanish): 655-660
- International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study.Mov Disord. 2006; 21: 916-923
- The metric properties of a novel non-motor symptoms scale for Parkinson's disease: results from an international pilot study.Mov Disord. 2007; 22: 1901-1911
- A review of health-related quality-of-life concepts and measures for Parkinson's disease.Qual Life Res. 1999; 8: 235-243
- Sydney multicenter study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years.Mov Disord. 2005; 20: 190-199
- Measuring symptom load in idiopathic Parknson's disease.Parkinsonism Rel Disord. 2007; 13: 284-289
- The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years.Mov Disord. 2008; 23: 837-844
- Neuropsychiatric symptoms in Parkinson's disease.Mov Disord. 2009; 24: 2175-2186
- Patients', doctors' and caregivers' assessment of disability using the UPDRS-ADL section: are these ratings interchangeable?.Mov Disord. 2003; 18: 985-992
- The impact of depressive symptoms in early Parkinson disease.Neurology. 2007; 69: 342-347
- The Grupo Centro for Study of Movement Disorders. Quality of life in Parkinson's disease: validation study of the PDQ-39 Spanish version.J Neurol. 1998; 245: 34-38
- Influence of clinical and demographic variables on quality of life in patients with Parkinson's disease.J Neurol Neurosurg Psychiatry. 1999; 66: 431-435
- The quality of life in Parkinson's disease.Mov Disord. 2000; 15: 216-223
- What contributes to quality of life in patients with Parkinson's disease?.J Neurol Neurosurg Psychiatry. 2000; 69: 308-312
- Psychometric characteristics of the Parkinson's Disease Questionnaire (PDQ-39) — Ecuadorian version.Parkinsonism Relat Disord. 2005; 11: 297-304
- Factors affecting the quality of life of patients with idiopathic Parkinson's disease — a cross-sectional study in an outpatient clinic attendees.Parkinsonism Relat Disord. 2005; 11: 465-468
- Determinants of quality of life in Brazilian patients with Parkinson's disease.Mov Disord. 2007; 22: 1408-1415
- Predictors and course of health-related quality of life in Parkinson's disease.Mov Disord. 2008; 23: 1420-1427
- Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trial.Mov Disord. 2008; 23: 653-659
- Determinants of disability and quality of life in mild to moderate Parkinson disease.Neurology. 2008; 70: 2241-2247
- Quality of life and depression in Parkinson's disease.J Neurol Sci. 2006; 248: 151-157
- Impact of newer pharmacological treatments on quality of life in patients with Parkinson's disease.CNS Drugs. 2008; 22: 563-586
- Determinants of health-related quality of life in Parkinson's disease: a systematic review.Parkinsonism Relat Disord. 2011; 17: 1-9
- Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson's disease.J Neurol. 2010; (PubMed PMID): 20957384
- Depression and anxiety in Parkinson disease.Nat Rev Neurol. 2010; 6: 243-245
- Anxiety disorders in Parkinson's disease: prevalence and risk factors.Mov Disord. 2010; 25: 838-845
- Anxiety and depression: main determinants of health-related quality of life in Brazilian patients with Parkinson's disease.Parkinsonism Relat Disord. 2008; 14: 102-108
- Quality of life in Parkinson's disease: the relative importance of the symptoms.Mov Disord. 2008; 23: 1428-1434
- A profile of neuropsychiatric problems and their relationship to quality of life for Parkinson's disease patients without dementia.Parkinsonism Relat Disord. 2008; 14: 37-42
- Anxiety, depression, and quality of life in Parkinson's disease.J Neuropsychiatry Clin Neurosci. 2009; 21: 413-419
- Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study.Arch Neurol. 2003; 60: 387-392
- Assessing quality of life in older adults with cognitive impairment.Psychosom Med. 2002; 64: 510-519
- Factors associated with nursing assistant quality-of-life ratings for residents with dementia in long-term care facilities.Gerontologist. 2005; 45: 106-114
- Insight, cognition and quality of life in Alzheimer's disease.J Neurol Neurosurg Psychiatry. 2010; 81: 331-336
- Improved quality of life and cognitive stimulation therapy in dementia.Aging Ment Health. 2006; 10: 219-226
- Measurement of overall quality of life in nursing homes through self-report: the role of cognitive impairment.Qual Life Res. 2007; 16: 1029-1037
- Quality of life and dementia. The voice of the person with dementia.Dementia. 2007; 6: 175-191
- Relationship between quality of life and cognitive decline in dementia.Dement Geriatr Cogn Disord. 2008; 25: 564-572
- Factors related to perceived quality of life in patients with Alzheimer's disease: the patient's perception compared with that of caregivers.Int J Geriatr Psychiatry. 2009; 24: 585-594
- Quality of life measurements in patients with Parkinson's disease: a community-based study.Eur J Neurol. 1998; 5: 443-450
- Depressive symptoms and cognitive status affect health-related quality of life in older patients with Parkinson's disease.J Am Geriatr Soc. 2007; 55: 1888-1890
- Is quality of life in non-demented Parkinson's disease patients related to cognitive performance? A clinic-based cross-sectional study.Eur J Neurol. 2008; 15: 128-133
- Psychometric attributes of the Scales for Outcomes in Parkinson's disease-Cognition (SCOPA-Cog), Spanish Version.Rev Neurol. 2008; 47: 337-343
- Quality of life in Serbian patients with Parkinson's disease.Qual Life Res. 2009; 18: 833-839
- Problems in using health survey questionnaires in older patients with physical disabilities. The reliability and validity of the SF-36 and the effect of cognitive impairment.J Eval Clin Pract. 2001; 7: 411-418
- Content validity for dementia of three generic preference based health related quality of life instruments.Qual Life Res. 2002; 11: 71-79
- Fatigue in patients with Parkinson's disease.Mov Disord. 1999; 14: 237-241
- Is fatigue an independent and persistent symptom in patients with Parkinson disease?.Neurology. 2004; 63: 1908-1911
- Impact of fatigue in Parkinson's disease: the Fatigue Impact Scale for Daily Use (D-FIS).Qual Life Res. 2006; 15: 597-606
- Clinical and psychosocial factors associated with fatigue in patients with Parkinson's disease.Parkinsonism Relat Disord. 2008; 14: 187-192
- The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease.Mov Disord. 2009; 24: 1641-1649
- The influence of fatigue on health-related quality of life in patients with Parkinson's disease.Acta Neurol Scand. 2003; 107: 1-6
- Impact of fatigue on quality of life in patients with Parkinson's disease.Eur J Neurol. 2008; 15: 475-480
- A community-based study of sleep disorders in patients with Parkinson's disease.Mov Disord. 1998; 13: 895-899
- Parkinson's disease and sleep.Sleep Med Rev. 2003; 7: 115-129
- The night time problems of Parkinson's disease.Clin Neuropharmacol. 1988; 11: 512-519
Happe S, Ludemann P, Berger K; FAQT study investigators. The association between disease severity and sleep-related problems in patients with Parkinson's disease. Neuropsychobiology 2002;46:90–6.
- Nocturnal sleep disturbances and daytime dysfunction in patients with Parkinson's disease and in their caregivers.Parkinsonism Relat Disord. 2004; 10: 157-168
- Mood and sleep in Parkinson's disease.J Clin Psychiatry. 2006; 67: 958-963
- Insomnia and depressive symptoms in patients with Parkinson's disease. Relationship to health-related quality of life. An interview study of patients living at home.Arch Gerontol Geriatr. 2001; 32: 23-33
- Association between patient education and health-related quality of life in patients with Parkinson's disease.Qual Life Res. 2004; 13: 81-89
- Health-related quality of life and sleep disorders in Parkinson's disease.Neurol Sci. 2003; 24: 209-210
- A pilot study on a specific measure for sleep disorders in Parkinson's disease: SCOPA-Sleep.Rev Neurol. 2006; 43: 577-583
- SCOPA-sleep and PDSS: two scales for assessment of sleep disorder in Parkinson's disease.Mov Disord. 2008; 23: 1681-1688
- Parkinson's disease sleep scale—validation of the revised version PDSS-2.Mov Disord. 2011; https://doi.org/10.1002/mds.23476
- Manifestations of Parkinson disease differ in association with REM sleep behavior disorder.Mov Disord. 2008; 23: 1665-1672
- How does Parkinson's disease affect quality of life? A comparison with quality of life in the general population.Mov Disord. 2000; 15: 1112-1118
- Quality of life and pain in Parkinson's disease: a controlled cross-sectional study.Parkinsonism Relat Disord. 2004; 10: 129-136
- Health related quality of life in Parkinson's disease: a prospective longitudinal study.J Neurol Neurosurg Psychiatry. 2000; 69: 584-589
- Sweating dysfunction in Parkinson's disease.Mov Disord. 2003; 18: 1459-1463
- Falls in Parkinson's disease. Causes and impact on patients' quality of life.Funct Neurol. 2005; 20: 163-168
- Macrogol for the treatment of constipation in Parkinson's disease. A randomized placebo-controlled study.Mov Disord. 2007; 15: 1239-1244
- The relationship between quality of life and swallowing in Parkinson's disease.Mov Disord. 2009; 15: 1352-1358
- The impact of and the factors associated with drooling in Parkinson's disease.Parkinsonism Relat Disord. 2010; 16: 475-477
- The non-motor symptom complex of Parkinson's disease: a comprehensive assessment is essential.Curr Neurol Neurosci Rep. 2005; 5: 275-283
- Quantitation of non-motor symptoms in Parkinson's disease.Eur J Neurol. 2008; 15: 2-7
- Prevalence of non-motor dysfunction among Parkinson's disease patients from a tertiary referral center in Mexico City.Clin Neurol Neurosurg. 2010; 112: 883-885
- Study of an integrated non-motor symptoms questionnaire for Parkinson's disease.Chin Med J (Engl). 2010; 123: 1436-1440
- Validation of the Chinese non-motor symptoms scale for Parkinson's disease: results from a Chinese pilot study.Clin Neurol Neurosurg. 2009; 111: 523-526
- The Impact of Non Motor Symptoms on Health-Related Quality of Life of Patients with Parkinson's Disease.Mov Disord. 2011; 26: 399-406
Article info
Publication history
Published online: May 30, 2011
Footnotes
☆Proceedings: 7th International Congress on Mental Dysfunctions & Other Non-Motor Features in Parkinson's Disease & Related Disorders December 9–12, 2010 in Barcelona, Spain
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© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
