Abstract
Recent studies have demonstrated that cytokines play an important role in the pathogenesis
of intracranial aneurysms (IAs). Interleukin-6 (IL-6) is an important proinflammatory
cytokine. In our study, we investigated the association of genetic variants within
the gene encoding interleukin-6-572G/C (IL-6-572G/C) with IAs in the Cantonese population.
The IL-6-572G/C gene polymorphisms in 182 IA cases and 182 controls were analyzed
using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Differences in genotype and allele frequencies between patients and controls were
tested. There is significant difference of IL-6-572G/C genotype frequencies in IA
group compared with control group (P=0.01), and significant difference of IL-6-572G/C allele frequency in IA group (11.54%)
compared with control group (4.95%) (P=0.001). Polymorphisms within IL-6-572G/C gene are associated with IAs in the Cantonese
population suggesting that the IL-6-572G/C gene is an important candidate gene for
IAs.
Keywords
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Article info
Publication history
Published online: April 18, 2011
Accepted:
March 18,
2011
Received in revised form:
March 17,
2011
Received:
January 9,
2011
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
