Dietary intake of metals and risk of Parkinson's disease: A case-control study in Japan

Published:April 18, 2011DOI:https://doi.org/10.1016/j.jns.2011.03.035

      Abstract

      Metals are involved in several important functions in the nervous system. Zinc and iron are increased and copper is decreased in the substantia nigra in Parkinson's disease (PD). However, epidemiological evidence for the association of dietary intake of metals with the risk of PD is limited. We investigated the relationship between metal consumption and the risk of PD in Japan using data from a multicenter hospital-based case-control study. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a self-administered diet history questionnaire. Higher intake of iron, magnesium, and zinc was independently associated with a reduced risk of PD: the adjusted OR in the highest quartile was 0.24 (95% CI: 0.10–0.57, P for trend=0.0003) for iron, 0.33 (95% CI: 0.13–0.81, P for trend=0.007) for magnesium and 0.50 (95% CI: 0.26–0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic and Personal

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Rivera-Mancía S.
        • Pérez-Neri I.
        • Ríos C.
        • Tristán-López L.
        • Rivera-Espinosa L.
        • Montes S.
        The transition metals copper and iron in neurodegenerative diseases.
        Chem Biol Interact. 2010; 186: 184-199
        • Barnham K.J.
        • Bush A.I.
        Metals in Alzheimer's and Parkinson's diseases.
        Curr Opin Chem Biol. 2008; 12: 222-228
        • Logroscino G.
        • Gao X.
        • Chen H.
        • Wing A.
        • Ascherio A.
        Dietary iron intake and risk of Parkinson's disease.
        Am J Epidemiol. 2008; 168: 1381-1388
        • Powers K.M.
        • Smith-Weller T.
        • Franklin G.M.
        • Longstreth Jr., W.T.
        • Swanson P.D.
        • Checkoway H.
        Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes.
        Neurology. 2003; 60: 1761-1766
        • Johnson C.C.
        • Gorell J.M.
        • Rybicki B.A.
        • Sanders K.
        • Peterson E.L.
        Adult nutrient intake as a risk factor for Parkinson's disease.
        Int J Epidemiol. 1999; 28: 1102-1109
        • Logroscino G.
        • Marder K.
        • Graziano J.
        • Freyer G.
        • Slavkovich V.
        • Lojacono N.
        • et al.
        Dietary iron, animal fats, and risk of Parkinson's disease.
        Mov Disord. 1998; 13: 13-16
        • Hughes A.J.
        • Daniel S.E.
        • Kilford L.
        • Lees A.J.
        Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
        J Neurol Neurosurg Psychiatry. 1992; 55: 181-184
        • Sasaki S.
        • Yanagibori R.
        • Amano K.
        Self-administered diet history questionnaire developed for health education: a relative validation of the test-version by comparison with 3-day diet record in women.
        J Epidemiol. 1998; 8: 203-215
        • Sasaki S.
        • Ushio F.
        • Amano K.
        • Morihara M.
        • Todoriki T.
        • Uehara Y.
        • et al.
        Serum biomarker-based validation of a self-administered diet history questionnaire for Japanese subjects.
        J Nutr Sci Vitaminol. 2000; 46: 285-296
        • Murakami K.
        • Sasaki S.
        • Takahashi Y.
        • Okubo H.
        • Hirota N.
        • Notsu A.
        • et al.
        Reproducibility and relative validity of dietary glycaemic index and load assessed with a self-administered diet-history questionnaire in Japanese adults.
        Br J Nutr. 2008; 99: 639-648
        • Science and Technology Agency
        Standard Tables of Food Composition in Japan.
        5th revised and enlarged ed. Printing Bureau of the Ministry of Finance, Tokyo, Japan2005 (in Japanese)
        • Science and Technology Agency
        Standard Tables of Food Composition in Japan, Fatty Acids Section.
        5th revised and enlarged ed. Printing Bureau of the Ministry of Finance, Tokyo, Japan2005 (in Japanese)
        • Willett W.
        • Stampfer M.J.
        Total energy intake: implications for epidemiologic analyses.
        Am J Epidemiol. 1986; 124: 17-27
        • Tanaka K.
        • Miyake Y.
        • Fukushima W.
        • Sasaki S.
        • Kiyohara C.
        • Tsuboi Y.
        • et al.
        Active and passive smoking and risk of Parkinson's disease.
        Acta Neurol Scand. 2010; 122: 377-382
        • Miyake Y.
        • Sasaki S.
        • Tanaka K.
        • Fukushima W.
        • Kiyohara C.
        • Tsuboi Y.
        • et al.
        Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.
        J Neurol Sci. 2010; 288: 117-122
        • Murakami K.
        • Miyake Y.
        • Sasaki S.
        • Tanaka K.
        • Fukushima W.
        • Kiyohara C.
        • et al.
        Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan.
        Nutrition. 2010; 26: 515-521
        • Murakami K.
        • Miyake Y.
        • Sasaki S.
        • Tanaka K.
        • Fukushima W.
        • Kiyohara C.
        • et al.
        Dietary intake of folate, vitamin B-6, vitamin B-12, and riboflavin and risk of Parkinson's disease: a case-control study in Japan.
        Br J Nutr. 2010; 104: 757-764
        • Miyake Y.
        • Fukushima W.
        • Tanaka K.
        • Sasaki S.
        • Kiyohara C.
        • Tsuboi Y.
        • et al.
        Dietary intake of antioxidant vitamins and risk of Parkinson's disease: a case-control study in Japan.
        Eur J Neurol. 2011; 18: 106-113
        • Friedman A.
        • Galazka-Friedman J.
        • Koziorowski D.
        Iron as a cause of Parkinson disease - a myth or a well established hypothesis?.
        Parkinsonism Relat Disord. 2009; 15: S212-S214
        • Wypijewska A.
        • Galazka-Friedman J.
        • Bauminger E.R.
        • Wszolek Z.K.
        • Schweitzer K.J.
        • Dickson D.W.
        • et al.
        Iron and reactive oxygen species activity in parkinsonian substantia nigra.
        Parkinsonism Relat Disord. 2010; 16: 329-333
        • Koziorowski D.
        • Friedman A.
        • Arosio P.
        • Santambrogio P.
        • Dziewulska D.
        ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and incidental Lewy body compared to control.
        Parkinsonism Relat Disord. 2007; 13: 214-218
        • Beard J.
        Iron deficiency alters brain development and functioning.
        J Nutr. 2003; 133: 1468S-1472S
        • Levenson C.W.
        • Cutler R.G.
        • Ladenheim B.
        • Cadet J.L.
        • Hare J.
        • Mattson M.P.
        Role of dietary iron restriction in a mouse model of Parkinson's disease.
        Exp Neurol. 2004; 190: 506-514
        • Hashimoto T.
        • Nishi K.
        • Nagasao J.
        • Tsuji S.
        • Oyanagi K.
        Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons.
        Brain Res. 2008; 1197: 143-151
        • Franco J.L.
        • Posser T.
        • Mattos J.J.
        • Trevisan R.
        • Brocardo P.S.
        • Rodrigues A.L.
        • et al.
        Zinc reverses malathion-induced impairment in antioxidant defenses.
        Toxicol Lett. 2009; 187: 137-143
        • Wang G.J.
        • Volkow N.D.
        • Fowler J.S.
        The role of dopamine in motivation for food in humans: implications for obesity.
        Expert Opin Ther Targets. 2002; 6: 601-609
        • Abbott R.D.
        • Petrovitch H.
        • White L.R.
        • Masaki K.H.
        • Tanner C.M.
        • Curb J.D.
        • et al.
        Frequency of bowel movements and the future risk of Parkinson's disease.
        Neurology. 2001; 57: 456-462
        • Ponsen M.M.
        • Stoffers D.
        • Booij J.
        • van Eck-Smit B.L.
        • Wolters E.Ch.
        • Berendse H.W.
        Idiopathic hyposmia as a preclinical sign of Parkinson's disease.
        Ann Neurol. 2004; 56: 173-181
        • Ekbom K.
        • Ulfberg J.
        Restless legs syndrome.
        J Intern Med. 2009; 266: 419-431