Abstract
The diagnosis of acute inflammatory demyelinating CNS conditions is complex and this
is reflected in variations in how cohorts are defined across studies. For some conditions
the diagnosis relies on whether it is monophasic or relapsing, in others the anatomical
site of inflammation is used as a means of categorisation. Clinical features such
as precipitants, gender and age may affect the probability of certain diagnoses, but
are not highly accurate. Exclusive features for the pathology are identifiable for
some but not all conditions, and are seldom available during life. Specific markers
such as antibodies are informative and new developments in this area are likely in
the near future. This review outlines the features and classification of acute disseminated
encephalomyelitis and contrasts it with other related conditions before attempting
to define a pragmatic organisation of these conditions based upon present evidence.
Keywords
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Article info
Publication history
Accepted:
March 16,
2011
Received in revised form:
March 15,
2011
Received:
April 14,
2010
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
