Abstract
Laquinimod is a small, novel, orally active, well-tolerated molecule that significantly
reduced gadolinium-enhancing lesions in patients with multiple sclerosis (MS). Orally
administered laquinimod was found to be present within the central nervous system
(CNS) in both healthy mice and mice with experimental autoimmune encephalomyelitis
(EAE). Laquinimod inhibits development of both acute and chronic EAE. Furthermore,
laquinimod minimizes inflammation, demyelination and axonal damage in MOG-induced
EAE in mice treated at disease induction and following clinical disease onset. In vitro, laquinimod down-regulates secretion of pro-inflammatory cytokines and enhances production
of anti-inflammatory cytokines from peripheral blood mononuclear cells (PBMCs) derived
from healthy subjects and untreated relapsing remitting (RR) MS patients. Additionally,
patients treated with laquinimod demonstrate up-regulation of brain-derived neurotrophic
factor (BDNF) in the serum. In conclusion, treatment with laquinimod is effective
in reducing inflammation, demyelination and axonal damage.
Keywords
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Article info
Publication history
Published online: March 23, 2011
Accepted:
February 16,
2011
Received in revised form:
October 11,
2010
Received:
May 31,
2010
Identification
Copyright
© 2011 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
