Abstract
In patients with idiopathic normal pressure hydrocephalus (iNPH), ventriculomegaly
and narrowed subarachnoid spaces at the high convexity appear in magnetic resonance
(MR) images before the occurrence of objective symptoms. In addition, quantitative
regional cerebral blood flow (rCBF) has been reported to be reduced in iNPH patients
with objective symptoms. To determine whether reduced rCBF is responsible for the
appearance of symptoms, we compared rCBF in patients with suspected iNPH with no objective
triad symptoms (NOS), iNPH patients with apparent objective triad symptoms (AOS) and
normal control subjects (NC). Regional CBF was quantified in 35 Regions-of-interest
(ROIs) by 123I-IMP single photon emission computed tomography (SPECT) using the autoradiography
(ARG) method. Multiple comparisons showed that, in all brain regions examined except
for in the frontal white matter, rCBF in the NOS group was significantly lower than
that in the NC group, but in all brain regions, not significantly different from that
of the AOS group. These results suggest that factors other than rCBF in the resting
state are responsible for the occurrence of objective symptoms of iNPH.
Keywords
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Article info
Footnotes
☆The address of institution in which the work was carried out: Department of Psychiatry, and Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka, Suita-city, Osaka 565-0871, Japan.
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© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
