Atrial fibrillation (AF) is the most common cardiac rhythm disorder with a substantial
risk of stroke and thromboembolism, that increases dramatically with age and the presence
of risk factors [
1
,
2
]. Thus, the prevention of stroke and thromboembolism is the cornerstone of AF management.
This risk is present irrespective of whether AF is paroxysmal, persistent or permanent
[
[3]
], and despite various debates on the place for antiplatelet therapy in thromboprophylaxis,
oral anticoagulation still remains the most effective means of stroke prevention in
AF [
4
,
5
].To read this article in full you will need to make a payment
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References
- Stroke and thromboembolism in atrial fibrillation: a systematic review of stroke risk factors, risk stratification schema and cost effectiveness data.Thromb Haemost. 2008; 99: 295-304
- Independent predictors of stroke in patients with atrial fibrillation: a systematic review.Neurology. 2007; 69: 546-554
- Paroxysmal atrial fibrillation, stroke risk and thromboprophylaxis.Thromb Haemost. 2008 Jul; 100: 11-13
- Contra: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”.Thromb Haemost. 2009 Nov; 102: 914-915
- Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”.Thromb Haemost. 2009 Nov; 102: 912-913
- Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.Ann Intern Med. 2007; 146: 857-867
- Euro Heart Survey Investigators. Guideline-adherent antithrombotic treatment is associated with improved outcomes compared with undertreatment in high-risk patients with atrial fibrillation. The Euro Heart Survey on Atrial Fibrillation.Am Heart J. 2007; 153: 1006-1012
- Underuse of oral anticoagulants in atrial fibrillation: a systematic review.Am J Med. 2010; 123 (e4): 638-645
- The likelihood of decreasing strokes in atrial fibrillation patients by strict application of guidelines.Europace. 2010; 12: 779-784
- Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W).Stroke. 2008; 39: 1482-1486
- Antithrombotic treatment and the risk of death and stroke in patients with atrial fibrillation and a CHADS2 score=1.Thromb Haemost. 2010; 103: 833-840
- Comparison of 12 risk stratification schemes to predict stroke in patients with nonvalvular atrial fibrillation.Stroke. 2008; 39: 1901-1910
- ATRIA Study Group. Comparison of risk stratification schemes to predict thromboembolism in people with nonvalvular atrial fibrillation.J Am Coll Cardiol. 2008; 51: 810-815
- Stroke risk in atrial fibrillation patients on warfarin. Predictive ability of risk stratification schemes for primary and secondary prevention.Thromb Haemost. 2009; 101: 367-372
- The CHADS2 score for stroke risk stratification in atrial fibrillation — friend or foe?.Thromb Haemost. 2010; 104: 45-48
- Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on Atrial Fibrillation.Chest. 2010; 137: 263-272
- Stroke severity in concomitant cardiac sources of embolism in patients with atrial fibrillation.J Neurol Sci. 2010; 298: 23-27
- Predicting left atrial thrombi in atrial fibrillation.Am Heart J. 2010; 159: 665-671
- Role of the CHADS2 score in the evaluation of thromboembolic risk in patients with atrial fibrillation undergoing transesophageal echocardiography before pulmonary vein isolation.J Am Coll Cardiol. 2009; 54: 2032-2039
- How effective are dose-adjusted warfarin and aspirin for the prevention of stroke in patients with chronic atrial fibrillation? An analysis of the UK General Practice Research Database.Thromb Haemost. 2009; 101: 527-534
- Pro: ‘Warfarin should be the drug of choice for thromboprophylaxis in elderly patients with atrial fibrillation’. Why warfarin should really be the drug of choice for stroke prevention in elderly patients with atrial fibrillation.Thromb Haemost. 2008; 100: 14-15
Article info
Publication history
Published online: September 02, 2010
Accepted:
August 6,
2010
Received in revised form:
August 6,
2010
Received:
July 29,
2010
Identification
Copyright
© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
