Advertisement
Short communication| Volume 298, ISSUE 1-2, P148-149, November 15, 2010

Download started.

Ok

Vertical wrinkling of the forehead or Procerus sign in Progressive Supranuclear Palsy

Published:September 02, 2010DOI:https://doi.org/10.1016/j.jns.2010.08.010

      Abstract

      ‘Procerus sign’ has been described as vertical wrinkles in the glabella region and bridge of the nose of patients with Progressive Supranuclear Palsy. The action of Corrugator and Orbicularis Oculi produce the vertical wrinkling. The relevance of this sign in early clinical diagnosis has been established and this sign has gained importance in literature and has been quoted as a useful sign in texts following the original description. We prospectively performed a cross sectional analysis of the facial appearance in subsequent Parkinsonism patients and found statistically significant presence of this sign in PSP compared to other Parkinsonian disorders. We recommend that this should be called “vertical wrinkling of the forehead” to avoid confusion and emphasize the dystonic nature of this condition rather than contraction of a single muscle as indicated by ‘Procerus sign’.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Romano S.
        • Colosimo C.
        Procerus sign in progressive supranuclear palsy.
        Neurology. 2001; 57: 1928-1929
        • Lepore F.E.
        • Moudgil S.S.
        • Romano S.
        • Colosimo C.
        Procerus sign in progressive supranuclear palsy.
        Neurology. 2002; 58: 1866-1867
        • Burn D.J.
        • Lees A.J.
        Progressive supranuclear palsy.
        in: Koller W.C. Melamed E. Handbook of Clinical Neurology. Parkinson's disease and related disorders. Part II. vol.84 (3rd series). The Netherlands Elsevier, Amsterdam2007: 327-349
        • Morimatsu M.
        Procerus sign in progressive supranuclear palsy and corticobasal degeneration.
        Intern Med. 2002 Dec; 41: 1101-1102
        • Shibasaki Warabi Y.
        • Nagao M.
        • Bandoh M.
        • Kanda T.
        • Hirai S.
        Procerus sign in corticobasal degeneration.
        Intern Med. Dec 2002; 41: 1217-1218
        • Litvan I.
        • Agid Y.
        • Calne D.
        • Campbell G.
        • Dubois B.
        • Duvoisin R.C.
        • et al.
        Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop.
        Neurology. 1996 Jul; 47: 1-9
      1. Standring S. Gray's anatomy: the anatomical basis of clinical practice. 40th ed. Churchill Livingstone/Elsevier, London, UK2008
        • Gilman S.
        • Wenning G.K.
        • Low P.A.
        • Brooks D.J.
        • Mathias C.J.
        • Trojanowski J.Q.
        • et al.
        Second consensus statement on the diagnosis of multiple system atrophy.
        Neurology. 2008; 71: 670-676
        • Hughes A.J.
        • Daniel S.E.
        • Kilford L.
        • Lees A.J.
        Accuracy of clinical diagnosis of idiopathic Parkinson's disease. A clinico-pathological study of 100 cases.
        JNNP. 1992; 55: 181-184
        • Williams D.R.
        • Lees A.J.
        Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges.
        Lancet Neurol. 2009; 8: 270-279
        • Tsuboi Y.
        • Josephs K.A.
        • Boeve B.F.
        • Litvan I.
        • Caselli R.J.
        • Caviness J.N.
        • et al.
        Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome.
        Mov Disord. 2005; 20: 982-987