We thank Dr. Ozyemisci-Taskiran for her interest and comments on our article [
]. She addressed several important issues in regard to studying cognitive performance in patients with neurological disorders. We concur that pharmacological interventions, intake of stimulants, exercise as well as motor impairments may influence cognitive performance measures and hence mask genuine diurnal variations in cognitive efficiency. Of course, it would be desirable to control for such potential confounds. However, in clinical settings such as vocational rehabilitation, it is often very difficult to establish such a controlled setup. For example, ethical limitations prohibit medication of healthy controls as well as discontinuation of patients' medication.
- Claros-Salinas D.
- Bratzke D.
- Greitemann G.
- Nickisch N.
- Ochs L.
- Schröter H.
Fatigue-related diurnal variations of cognitive performance in multiple sclerosis and stroke patients.
J Neurol Sci. 2010; 295: 75-81
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- Fatigue-related diurnal variations of cognitive performance in multiple sclerosis and stroke patients.J Neurol Sci. 2010; 295: 75-81
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Published online: September 01, 2010
Accepted: August 5, 2010
Received: July 29, 2010
© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.