We thank Dr. Ozyemisci-Taskiran for her interest and comments on our article [
[1]
]. She addressed several important issues in regard to studying cognitive performance
in patients with neurological disorders. We concur that pharmacological interventions,
intake of stimulants, exercise as well as motor impairments may influence cognitive
performance measures and hence mask genuine diurnal variations in cognitive efficiency.
Of course, it would be desirable to control for such potential confounds. However,
in clinical settings such as vocational rehabilitation, it is often very difficult
to establish such a controlled setup. For example, ethical limitations prohibit medication
of healthy controls as well as discontinuation of patients' medication.To read this article in full you will need to make a payment
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References
- Fatigue-related diurnal variations of cognitive performance in multiple sclerosis and stroke patients.J Neurol Sci. 2010; 295: 75-81
- Modern mental chronometry.Biol Psychol. 1988; 26: 3-67
- Donders's assumption of pure insertion: an evaluation on the basis of response dynamics.Acta Psychol. 1999; 102: 43-75
- Fatigue in neurological disorders.Lancet. 2004; 363: 978-988
Article info
Publication history
Published online: September 01, 2010
Accepted:
August 5,
2010
Received:
July 29,
2010
Identification
Copyright
© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
