Abstract
Background
Stroke is one of the most disabling and burdensome health conditions worldwide, but
no prospective population-based study has been conducted in Spain. Our aim was to
assess age- and gender incidence rates of cerebrovascular disease, including stroke
and transient ischemic attack, in three populations in central Spain using data from
the NEDICES (Neurological Diseases in Central Spain), a population-based survey of
elderly participants.
Methods
Individuals were evaluated at baseline (1994–1995) and at follow-up (a median of 3.2 years later in 1997–1998). The evaluation included a screening questionnaire for stroke
and a neurological assessment (when possible).
Results
Of 5278 participants evaluated at baseline, there were 257 prevalent stroke cases.
Seventy-five incident patients with cerebrovascular disease (57 stroke cases and 18
transient ischemic attacks cases) were identified among 3914 individuals assessed
at follow-up. Average annual incidence rate (per 1000 person-years) in the population
aged 65 to 85 and over years, adjusted to the standard European population, was 5.1
(95% CI, 3.7 to 6.6) for all types of cerebrovascular disease. Age-specific incidence
rates of cerebrovascular disease increased with advancing age. Age and diabetes mellitus
were independent risk factors for cerebrovascular disease. Number of vascular risk
factors present at baseline showed an independent positive and graded association
with incident cerebrovascular disease.
Conclusions
In the NEDICES study, incidence of cerebrovascular disease increased with age beyond
age 85. Our incidence rates provide new estimates for projection of future burden
of disease in Spain.
Keywords
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Article info
Publication history
Published online: September 07, 2010
Accepted:
August 5,
2010
Received in revised form:
July 23,
2010
Received:
April 23,
2010
Identification
Copyright
© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
