Abstract
The aim of this study was to evaluate whether proconvulsive interleukin-1β (IL-1β)
and anticonvulsive IL-1 receptor antagonist (IL-1Ra) are markers of the effectiveness
of treatment in patients with West syndrome (WS). We analyzed serum and cerebrospinal
fluid (CSF) levels of IL-1β and IL-1Ra in 13 patients with WS. The serum IL-1Ra levels
postimprovement (average, 384.6 pg/ml) in clinical and electroencephalographic (EEG) findings were significantly higher
than the preimprovement values (average, 240.6 pg/ml). No significant difference in the preimprovement serum IL-1Ra levels was noted
between the anticonvulsant (AED)-response and adrenocorticotropic hormone (ACTH)-response
groups (260.0 pg/ml, n=7 vs. 218.0 pg/m, n=6) and the cryptogenic and symptomatic groups (290.1 pg/ml, n=4 vs. 218.3 pg/m, n=9), respectively; as for the preimprovement CSF levels, the AED-response group (114.5 pg/m; n=3) and ACTH-response groups (138.0 pg/m; n=6) and the cryptogenic (59.3 pg/m; n=3) and symptomatic groups (165.6 pg/m; n=6), respectively. Serum and CSF IL-1β levels were detected only in 3 patients preimprovement.
Serum IL-1Ra levels were elevated subsequent to resolution of clinical and EEG findings
in WS patients. A larger study should be conducted to clarify whether an immunological
processes are concerned with the pathophysiology of WS.
Keywords
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Article info
Publication history
Published online: September 01, 2010
Accepted:
July 27,
2010
Received in revised form:
July 24,
2010
Received:
March 25,
2010
Identification
Copyright
© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
