Understanding disease pathology regarding disorders of the nervous and vascular systems
as well as successfully treating both acute and chronic degenerative diseases has
proven to be one of the most challenging issues the scientific and medical communities
have faced in the past century. It is estimated that more than 500 million individuals worldwide are suffering from such disorders as stroke, Alzheimer's-type
dementia, Parkinson's disease, traumatic brain injury, mild cognitive impairment,
and hypertension. It is predicted that, in the coming years, this number is likely
to increase significantly. One reason for this is the significant risks associated
with the nervous and vascular systems. Recent observations have shown that organs,
such as the brain, are highly susceptible to cellular injury via free radical oxidation
due to the large amount of oxygen consumed by the brain and the relatively limited
ability to overcome cellular injury, and it is theorized that these factors lead to
the production of cellular oxidative stress. Current studies estimate that the high
levels of oxidative stress could potentially play a significant role in the onset
of pathological complications as well as being a major player in aging mechanisms.
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Article info
Publication history
Published online: August 27, 2010
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Copyright
© 2010 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
