Research Article| Volume 283, ISSUE 1-2, P137-138, August 15, 2009

Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients

Published:March 23, 2009DOI:


      In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of ε2 allele and less frequent in the carriers of ε4 allele.


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