Abstract
Vascular cognitive impairment is an important cause of cognitive decline in the elderly.
Ischemic lesions in the brain have an influence on the natural history of dementia.
Vascular dementia can be caused by small-vessels disease (S-VaD) or by large-artery
atherosclerosis with vascular lesions in strategic areas of the brain (M-VaD). In
both cases changes in white matter are observed. In 60 patients with S-VaD and in
34 with M-VaD the presence of vascular and biochemical risk factors was evaluated
and compared to age and sex matched 126 controls without dementia.
Coronary artery disease, atrial fibrillation, hypertension and strokes were observed
more frequently in both investigated groups. Of biochemical risk factors, hyperhomocysteinemia
(associated with low levels of folic acid and vitamin B 12) and low HDL cholesterol
levels were found in both forms of VaD.
Keywords
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References
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- Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction. The Hisayama study.Cerebrovasc Dis. 2002; 13: 9-15
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Article info
Publication history
Published online: April 02, 2009
Identification
Copyright
© 2009 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
