Abstract
Paraoxonase activity, homocysteine level and lipids were determined in 120 patients
with dementia (51 with Alzheimer disease, 28 with dementia of vascular origin, 41
with mixed dementia), 45 with mild cognitive impairment and in 61 age and sex matched
controls without dementia. Paraoxonase activity was decreased in Alzheimer disease
and in mixed dementia as compared with control group. In the same forms of dementia
homocysteine levels were increased. In Alzheimer disease paraoxonase activity was
negatively correlated with homocysteine levels. Minimental State Examination results
showed positive correlation with paraoxonase activity. The results suggest an important
role of oxidative stress in the development of the forms of dementia with prevailing
neurodegeneration.
Keywords
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Article info
Publication history
Published online: March 06, 2009
Identification
Copyright
© 2009 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
