Abstract
The aim of this study was to investigate everyday executive functioning abilities
in patients with focal cerebellar lesions using an executive battery sensitive for
the detection of damage to the prefrontal cortex, including a “real life” situation
task. Eleven patients with focal cerebellar infarcts were studied prospectively after
their injury. All subjects underwent a complete neurological, neuropsychiatric, and
neuropsychological examination, as well as a specific computerized battery (Test of
Attentional Performance), and an “ecological” test: the Multiple Errands Task-hospital
version (MET-hv, adapted version). Significant differences were found between patients
and normal controls in language and executive functions tasks. Significant differences
were observed in the flexibility subscale of the Test of Attentional Performance and
several subscales of the MET-hv (total amount of failures, interpretation failures,
task completion score, and inefficiencies subscale). This study supports previous
reports showing a pattern of cognitive abnormalities following focal cerebellar damage
that includes impairments of executive function. Moreover, it suggests that the ecological
test used in this investigation might be useful for the detection of deficits in real-life
executive functioning among this patient population.
Keywords
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References
- The cerebellar cognitive affective syndrome.Brain. 1998; 121: 561-579
- Early infantile autism.Int Rev Neurobiol. 1997; 41: 367-386
- An MRI study of midbrain morphology in patients with schizophrenia: relationship to psychosis, neuroleptics, and cerebellar neural circuitry.Biol Psychiatry. 2001; 49: 13-19
- Morphometry of individual cerebellar lobules in schizophrenia.Am J Psychiatry. 2001; 158: 952-954
- Evaluation of cerebellar size in attention-deficit hyperactivity disorder.J Child Neurol. 1998; 13: 434-439
- Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder.Arch Gen Psychiatry. 2001; 58: 289-295
- Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults.Lancet. 1999; 353: 1662-1667
- Cognitive impairment in young adults with infratentorial infarcts.Neurology. 1998; 51: 433-440
- Neuropsychological disturbances in cerebellar infarcts.Acta Neurol Scand. 2000; 102: 363-370
- Roberts A.C. Robbins T.W. Weiskrantz L. The prefrontal cortex. Executive and cognitive functions. Oxford University Press, Oxford1998
- The assessment of executive functions: coming out of the office.Brain Inj. 2004; 18: 1067-1081
- Neuropsychological assessment in brain injury.in: Eisenburgh M.G. Greziak R.C. Advances in Clinical Rehabilitation. vol. 1. Srpinger, New York1987: 47-92
- Estimation of premorbid intelligence: The word accentuation test—Buenos Aires version.J Clin Exp Neuropsych. 2000; 22: 677-685
- Wechsler memory scale-revised (WMSR).The Psychological Corporation, San Antonio1987
- Partington's pathway test.Psych Center. 1949; 1: 9-20
- L'examen clinique en psychologie.Presse Universitaire de France, Paris1958
- A simple objective test for measuring flexibility in thinking.J Gen Psychol. 1958; 39: 22-26
- Testbattere zur aufmerksamkeitsprüfung (TAP) — Spanish version.Psytest, Freiburg1995
- Ecological validity of a simplified version of the multiple errands shopping test.J Int Neuropsychol Soc. 2003; 9: 31-44
- Deficits in strategy application following frontal lobe damage in man.Brain. 1991; 114: 727-741
- The cerebellum contributes to higher functions during development: evidence from a series of children surgically treated for posterior fossa tumours.Brain. 2000; 123: 1051-1061
- Verbal fluency and agrammatism.Int Rev Neurobiol. 1997; 41: 325-339
- The frontal lobes.Raven Press, New York1986
- Decision-making processes following damage to the prefrontal cortex.Brain. 2002; 125: 624-639
- Higher cortical functions in man.Tavistock, London1966
- An emerging concept. The cerebellar contribution to higher function.Arch Neurol. 1991; 48: 1178-1187
- Projections to the basis pontis from the superior temporal sulcus and superior temporal region in the rhesus monkey.J Comp Neurol. 1991; 308: 224-248
- Prefrontal cortex projections to the basilar pons in rhesus monkey: implications for the cerebellar contribution to higher function.Neurosci Lett. 1995; 199: 175-178
- Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function.Science. 1994; 266: 458-461
- Pathological laughter and crying: a link to the cerebellum.Brain. 2001; 124: 1708-1719
Article info
Publication history
Published online: March 06, 2009
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© 2009 Elsevier B.V. Published by Elsevier Inc. All rights reserved.