Abstract
To date, there is no widely accepted clinical scale to monitor the evolution of depressive
symptoms in demented patients. We assessed the sensitivity to treatment of a validated
French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five
routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia
and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) “depressive mood” item as gold
standard, a receiver operating characteristic curve (ROC) analysis assessed the validity
of HoNOS65+F “depressive symptoms” item score changes. Unlike Geriatric Depression
Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores
decreased and Global Assessment Functioning Scale score increased significantly from
admission to discharge. Amongst HoNOS65+F items, “behavioural disturbance”, “depressive
symptoms”, “activities of daily life” and “drug management” items showed highly significant
changes between the first and last day of hospitalization. The ROC analysis revealed
that changes in the HoNOS65+F “depressive symptoms” item correctly classified 93%
of the cases with good sensitivity (0.95) and specificity (0.88) values. These data
suggest that the HoNOS65+F “depressive symptoms” item may provide a valid assessment
of the evolution of depressive symptoms in demented patients.
Keywords
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Article info
Publication history
Published online: March 04, 2009
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© 2009 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
