Abstract
Background
Although dementia has a great impact on public health, there are few reports on dementia
incidence and risk factors for Asian populations.
Objectives
To determine incidence and risk factors of dementia, Alzheimer disease (AD), and vascular
dementia (VaD) among Japanese women.
Methods
Between 1992 and 1996, 1637 non-demented women aged ≥60 years were followed for an average of 5.9 years in RERF's Adult Health Study. Dementia
diagnoses were made during biennial health examinations using a two-phase procedure.
DSM IV criteria were used for diagnosing dementia, NINCDS-ADRDA for AD, and NINDS-AIREN
for VaD. Potential risk factors were analyzed using Poisson regression analysis.
Results
161 cases of dementia (109 of AD and 56 of VaD, based on individual criteria) were
newly diagnosed. Incidence increased dramatically with age, especially for AD. Probable
AD decreased with increasing education level. Probable VaD was significantly associated
with hypertension and stroke. Age at menopause did not show any effect on dementia.
All dementia and probable AD were significantly associated with grip strength.
Conclusions
AD is predominant in dementia incidence among Japanese women. Modification of stroke
risk factors and improvement of physical fitness may help prevent dementia.
Keywords
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Article info
Publication history
Published online: March 06, 2009
Identification
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© 2009 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
