Abstract
The observation of decline in mitochondrial electron transport chain function, specifically
at complex I, in patients with Parkinson's disease (PD) has been reported by several
groups. This study investigates whether a defect of mitochondrial function is present
in the platelets of PD patients from an Indian population. We found that the NADH
dehydrogenase activity in the platelets of PD patients is lower than that in healthy
age- and gender-matched controls, while the succinate dehydrogenase activity was similar
in both groups. Furthermore, there was no change in either of the activities in patients
with Parkinson plus syndrome or atypical parkinsonism. This is the first report indicating
a decline in mitochondrial function in the platelets of PD patients from the Indian
population, offering further support to the role of a mitochondrial defect in PD.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Mitochondrial complex I deficiency in Parkinson's disease.J Neurochem. 1990; 54: 823-827
- Anatomic and disease specificity of NADH CoQ10 reductase (complex I) deficiency in Parkinson's disease.J Neurochem. 1990; 55: 2142-2145
- Unaltered aconitase activity but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease.Neurosci Lett. 1994; 169: 126-128
- Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases.J Neurol Sci. 1998; 158: 24-29
- Bindoff LA, Birch-Machin M, Cartlidge NEF, Parker Jr. WD, Turnbull DM. Mitochondrial function in Parkinson's disease.Lancet. 1989; 334: 49
- Mitochondrial oxidative phosphorylation defects in Parkinson's disease.Ann Neurol. 1991; 30: 332-339
- Is Parkinson's disease a mitochondrial disorder?.J Neurol Sci. 1992; 107: 29-33
- Mitochondrial respiratory chain activity in skeletal muscle from patients with Parkinson's disease.Neurology. 1993; 43: 2258-2262
- Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy.J Neurol Sci. 1994; 125: 95-101
- Evidence for mitochondrial dysfunction in Parkinson's disease: a critical appraisal.Mov Disord. 1994; 9: 125-138
- Respiratory chain activities in lymphocytes from untreated patients with Parkinson's disease.Clin Chem. 1993; 39: 667-669
- Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease.J Neural Transm Parkinson's Dis Sect. 1994; 8: 223-228
- Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease.Brain. 1992; 115: 333-342
- No evidence for altered muscle mitochondrial function in Parkinson's disease.J Neurol Neurosurg Psychiatr. 1993; 56: 477-480
- Respiratory chain and mitochondrial DNA in muscle and brain in Parkinson's disease patients.Neurology. 1993; 43: 2262-2268
- Unaltered respiratory chain enzyme activity and mitochondrial DNA in skeletal muscle from patients with idiopathic Parkinson's syndrome.Eur Neurol. 1994; 34: 263-267
- Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease.J Neural Transm. 1992; 4: 27-34
- Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from untreated Parkinson's disease patients.Neurology. 1996; 46: 1343-1346
- Studies on the serotonin transporter in platelets.Experientia. 1988; 44: 127-130
- Characterization of the neuronal dopamine transporter DAT in human blood platelets.Neurosci Lett. 2006; 399: 197-201
- The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders.Arch Gen Psychiatry. 1977; 34: 509-516
- Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.Ann Neurol. 1997; 42: 261-264
- Altered redox state of platelet coenzyme Q10 in Parkinson's disease.J Neural Transm. 2000; 107: 41-48
- Reduced platelet glutamate uptake in Parkinson's disease.J Neural Transm. 1999; 106: 685-692
- Dose regimen of deprenyl (selegiline) and platelet MAO activities.Acta Neurol Scand Suppl. 1983; 95: 87-89
- Platelet monoamine oxidase in Parkinson patients: effect of L-deprenyl therapy.J Neural Transm Park Dis Dement Sect. 1989; 1: 189-194
- Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes.Brain. 1993; 116: 1451-1463
- Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background.Mitochondrion. 2008; 8: 219-228
- Abnormalities of the electron transport chain in idiopathic Parkinson's disease.Ann Neurol. 1989; 26: 719-723
- Low platelet mitochondrial Complex I and Complex II/III activity in early untreated Parkinson's disease.Ann Neurol. 1995; 37: 714-722
- Effect of aging and dopaminomimetic therapy on mitochondrial respiratory function in Parkinson's disease.Mov Disord. 1992; 7: 228-231
- Mitochondrial complex I, II/III, and IV activities in familial and sporadic Parkinson's disease.Int J Neurosci. 2005; 115: 479-493
- Phylogeny and antiquity of M macrohaplogroup inferred from complete mtDNA sequence of Indian specific lineages.BMC Evol Biol. 2005; 5: 26
- Different genetic components in Ethiopian population, identified by mtDNA and Y-chromosome polymorphisms.Am J Hum Genet. 1998; 62: 420-434
- Deep common ancestry of Indian and western-Eurasian mitochondrial DNA lineages.Curr Biol. 1999; 9: 1331-1334
- Phylogeographic differentiation of mitochondrial DNA in Han Chinese.Am J Hum Genet. 2002; 70: 635-651
- Mitochondrial DNA sequence polymorphisms of five ethnic populations from northern China.Hum Genet. 2003; 113: 391-405
- Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson's disease: preliminary study.Neurol India. 2006; 54: 390-393
- Protein measurement with the Folin phenol reagent.J Biol Chem. 1951; 193: 265-275
- Carbidopa/levodopa and selegiline do not affect platelet mitochondrial function in early parkinsonism.Neurology. 1995; 45: 344-348
- Mammalian succinate dehydrogenase.Methods Enzymol. 1978; 53: 466-483
- Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson's Disease Research Group.Ann Neurol. 1992; 32: 782-788
- Mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson's Disease Research Group.Ann Neurol Suppl. 1992; 32: 116-124
- Platelet mitochondrial respiratory chain function in Parkinson's disease.Mov Disord. 1997; 12: 3-8
- Relationships among molecular, genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues.BBA — Molecular Basis of Disease. 2009; 1792: 68-74
- Mitochondria in the aetiology and pathogenesis of Parkinson's disease.Lancet Neurol. 2008; 7: 97-109
Article info
Publication history
Published online: January 28, 2009
Accepted:
December 17,
2008
Received in revised form:
November 25,
2008
Received:
September 5,
2008
Identification
Copyright
© 2009 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
