I would like to thank Dr. Sullivan for his positive comments regarding my recent proposal
suggesting maternal hypothyroxinemia as a potential cause of autism. He addresses
the worrying trend of a progressive decline in iodine ingestion in the U.S. among
women of childbearing age. Maternal iodine deficiency causes maternal hypothyroxinemia
and further enhances the effects of environmental antithyroid and goitrogenic pollutants
that are postulated to cause autism and attention-deficit hyperactivity disorder.
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References
- Iodine supplementation during pregnancy: a public health challenge.Trends in Endocrinology and Metabolism. 2007; 18: 338-343
- Role of thyroid hormone during early brain development.Eur J Endocrinol. 2004; 151: 1-14
- Maternal hypothyroxinaemia during (early) gestation.Lancet. 2005; 365: 1604-1606
- Editorial: diagnosing thyroid dysfunction in pregnant women: is case finding enough?.J Clin Endocrinol Metabolism. 2007; 92: 39-41
Article info
Publication history
Accepted:
September 17,
2008
Received:
September 15,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.