Abstract
We made a cross-sectional study to analyze glucose intolerance of myotonic dystrophy
type 1 (DM1) with several examination including oral glucose tolerance test (OGTT),
insulin tolerance test (ITT) and adiponectin. Ninety-five DM1 patients participated
in this study. Health examination data from general people were used as controls.
In DM1, homeostasis model assessment-insulin resistance (HOMA-IR) was higher than
control even in the lowest fasting blood sugar (FBS) stage (<80 mg/dl) and insulin sensitivity assessed by ITT was low regardless of their FBS.
Insulinogenic index of DM1 was positively correlated to HOMA-IR. Insulinogenic index
and sum of IRI in OGTT were markedly elevated in the lowest FBS stage and declined
along with elevation of FBS. Consequently, as many as 13.3% of DM1 patients with 90–110 mg/dl
of FBS exhibited DM pattern, while only 1.9% in control. Adiponectin was higher in
DM1 than control. Although age correlated with adiponectin in both control and DM1,
its impact was stronger in DM1.
DM1 predisposes insulin resistance and compensatory hyperinsulinemia exist even in
patients with low FBS. We should pay attention to glucose intolerance of DM1 patients
earlier than that of the general population. It seemed that 90 mg/dl of FBS is an
important index as an indication of careful managements.
Keywords
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Article info
Publication history
Accepted:
August 26,
2008
Received in revised form:
July 12,
2008
Received:
May 12,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
