Abstract
Multiple sclerosis (MS) is characterised by focal areas that undergo cycles of demyelination
and remyelination. Although conventional magnetic resonance imaging is very effective
in localising areas of damage, these techniques are not pathology specific. A newer
technique, T2 relaxation, can separate water from brain into three compartments: (1) a long T2 component (>2 s) arising from CSF, (2) an intermediate T2 component (~80 ms) attributed to intra- and extra-cellular water and (3) a short T2 component (~20 ms) assigned to water trapped in between the myelin bilayers (termed myelin water).
Histological evidence shows that myelin water is a specific marker of myelination.
The goal of this work was to follow changes in total water content (WC) and myelin
water fraction (MWF) in evolving MS lesions over one year. Multi-echo T2 relaxation data was collected and used to measure water content and myelin water
fraction from three new MS lesions in two patients. WC increased in the three large
(>1 cm3) lesions at lesion appearance and remained elevated in the central core. Two lesions
showed low MWF in the core suggesting demyelination upon first appearance. At later
time points, one lesion showed a decrease in volume of low MWF, reflecting remyelination
whereas the volume of low MWF in the other lesion core remained constant. This work
provides evidence that MWF and WC can monitor demyelination and remyelination in MS.
Keywords
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Article info
Publication history
Accepted:
August 21,
2008
Received in revised form:
August 18,
2008
Received:
March 3,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
