Abstract
Osteopontin (OPN) was suggested to have a role in the pathophysiology of MS and in
bone metabolism. However, we formerly reported increased presence of osteoporosis
in MS patients independent of corticosteroid treatment, there is only limited information
about the mechanism of bone loss. In this study, we investigated the role of OPN on
bone mineral density in MS patients. Thirty-three relapsing–remitting (RR), 12 secondary
progressive (SP), and 5 primary progressive (PP) MS patients and 30 healthy controls
were prospectively enrolled. Students' t test, chi-square test, and Pearson correlations were used. The mean OPN level was
155.4±81.8 ng/ml in controls, and 15.9±36.2 ng/ml in MS patients (p<0.001).No statistical difference was observed among RR, SP and PPMS patients (p=0.162). No relationship was found between OPN levels and age at onset of disease (p=0.830), gender (p=0.785), MS subtypes (p=0.330), disease duration (p=0.744), or EDSS scores (p=0.633).About 34% of MS patients versus 10.3% of controls had osteoporosis (p=0.017).Osteopontin levels showed no significant correlation with osteoporosis in controls,
but were lower in MS patients with osteoporosis in femur neck (r=0.85, p=0.010).The cumulative dose of corticosteroid treatment did not correlate with OPN
levels (p=0.285).In conclusion, our results suggest that OPN may have a role as a shared cytokine
in pathogenesis of MS and osteoporosis.
Keywords
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Article info
Publication history
Accepted:
August 20,
2008
Received in revised form:
July 21,
2008
Received:
March 29,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.