Abstract
High resolution positron emission tomography (PET) with the newly developed HRRT scanner
(Siemens/CTI) permits the reliable quantification of 18-Fluorodeoxyglucose (FDG) uptake
as a marker of neuronal activity in small subcortical nuclei which are involved in
the pathophysiology of Parkinson's disease (PD). We investigated the normalized cerebral
metabolic rates of glucose (nCMRGlc) with HRRT PET in basal ganglia (BG) nuclei of
10 early-stage PD patients and in 9 healthy volunteers. PET data were co-registered
to magnetic resonance images and analyzed in a three-dimensional volume-of-interest
(VOI) approach. After normalization for global brain activity, PD patients showed
a significantly higher nCMRGlc than controls bilaterally in the BG output nuclei (pallidum,
substantia nigra) and unilateral in the caudate and putamen. The metabolic activity
of the nucleus accumbens, the subthalamic nucleus, the corpus amygdaloideum and the
red nucleus was normal. These first HRRT PET data in living parkinsonian humans extend
previous brain imaging findings of abnormal network activity in the BG and confirm
output nuclei and striatal overactivation also in early stage PD patients.
Keywords
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Article info
Publication history
Accepted:
August 19,
2008
Received in revised form:
August 14,
2008
Received:
May 6,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
