Abstract
Sporadic Parkinson's disease (PD) is a frequent neurodegenerative movement disorder.
Both environmental and genetic factors have been studied in the etiology of PD. Among
genetic factors, increasing evidences suggest that deletion/insertion (D/I) gene polymorphism
of the angiotensin I-converting enzyme (ACE) may be involved in the pathogenesis of
PD and in the occurrence of the adverse effects of chronic l-dopa therapy. We investigated this hypothesis by evaluating the frequency of the
ACE gene D/I polymorphism in 120 Italian PD patients and 132 controls. Out of the
120 PD patients, 91 were under chronic l-dopa treatment. Our results revealed no difference in ACE I/D genotype (χ2=0.79, p=0.66) and allele (χ2=0.34, p=0.56) frequencies between PD and controls. We also failed to observe any significant
association with the occurrence of l-dopa-induced adverse effects in long-term treated PD patients, thereby excluding
the presence of an association between ACE I/D genotypes and the genetic susceptibility
to PD and the development of adverse effect of chronic l-dopa therapy.
Keywords
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Article info
Publication history
Accepted:
August 13,
2008
Received in revised form:
July 3,
2008
Received:
February 15,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
