Abstract
In experimental autoimmune encephalomyelitis (EAE), several target antigens of encephalitogenic
T- and B-cell responses have been identified. However, in human multiple sclerosis
(MS) the target antigens of pathogenic T and B cells have remained conjectural. Here
we discuss how recent methodological advances have offered new insights into the nature
of B- and T-cell receptor repertoires expressed in MS tissues, and how novel approaches
have helped to identify neurofascin as a target of anti-axonal autoantibodies in MS
and EAE.
Keywords
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Article Info
Publication History
Accepted:
July 4,
2008
Received in revised form:
July 2,
2008
Received:
February 11,
2008
Footnotes
☆This article is based on a presentation given at the European Charcot Foundation Symposium “Treatment Targets in Multiple Sclersosis”, held in Fiuggi, Italy on November 29–30 and December 1, 2007. The article was compiled from previous publications of the authors (Refs. [
17
, 22
, 35
, 37
]).Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
