Abstract
By studying gene transcripts in active lesions of multiple sclerosis via robotic sequencing
and gene chips, as well as studying the very same tissue via proteomics, we have discovered
several targets at the tipping points in pathophysiologic pathways controlling relapse
and remission in multiple sclerosis. In this Charcot Lecture, I shall focus on osteopontin—the
binding partner for alpha4 beta 1 integrin, on alpha B crystallin and on two members
of the coagulation cascade tissue factor and the inhibitor of protein C. These four
proteins are critical in controlling relapse and remission in MS.
Keywords
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Article info
Publication history
Accepted:
June 27,
2008
Received:
April 30,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
