Abstract
Understanding the mechanisms of tissue injury in multiple sclerosis brains is a prerequisite
for specific protective therapy. Here we review recent data, suggesting that demyelination
and axonal injury in MS may be induced by different mechanisms involving adaptive
and innate immunity. The relative contribution of the different immune reactions may
in part explain the inter-individual and stage dependent heterogeneity of multiple
sclerosis lesions.
Keywords
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Article info
Publication history
Accepted:
April 2,
2008
Received in revised form:
March 28,
2008
Received:
February 4,
2008
Identification
Copyright
© 2008 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
