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Nutritional optic neuropathies

  • C. Orssaud
    Correspondence
    Corresponding author. Department of Ophthalmology, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, 20, Rue Leblanc, 75015 Paris, France. Tel.: +33 1 56 09 34 98; fax: +33 1 56 09 36 28.
    Affiliations
    Department of Ophthalmology, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, 20, Rue Leblanc, 75015 Paris, France

    Department of Ophthalmology, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France
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  • O. Roche
    Affiliations
    Department of Ophthalmology, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France
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  • J.L. Dufier
    Affiliations
    Department of Ophthalmology, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, 20, Rue Leblanc, 75015 Paris, France

    Department of Ophthalmology, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France
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      Abstract

      Nutritional deficiency may be the cause of a genuine optic neuropathy, sometimes associated with involvement of the peripheral nervous system. Nutritional optic neuropathies are usually bilateral, painless, chronic, insidious and slowly progressive. Most often, they present as a non-specific retrobulbar optic neuropathy. The differential diagnosis with other causes of optic nerve involvement, in particular of toxic origin, may be particularly difficult. Nutritional deficits are often associated with toxic effects from alcohol and tobacco; therefore, the separation of the nutritional and toxic components is often illusory and artificial. The pathophysiological mechanisms involved in nutritional – and toxic – optic neuropathies affect biochemical pathways involved in cell energetic production, correction of oxidative stress and quenching of free radicals. The recognition of these mechanisms could provide future therapeutic alternatives. Currently, the treatment is limited to the intensive use of vitamins with variable results in individual cases, and to the implementation of preventive measures, when feasible.

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      References

        • Milea D.
        Nutritional, toxic and drug-induced optic neuropathies.
        Rev Prat. 2001; 51: 2215-2219
        • Woon C.
        • Tang R.A.
        • Pardo G.
        Nutrition and optic nerve disease.
        Semin Ophthalmol. 1995; 10: 195-202
        • Rizzo III, J.F.
        Adenosine triphosphate deficiency: a genre of optic neuropathy.
        Neurology. 1995; 45: 11-16
        • Lopez-Hernandez N.
        • Garcia-Escriva A.
        • Pampliega-Perez A.
        • Alvarez-Sauco M.
        • Martin-Estefania C.
        • Asensio-Asensio M.
        Peripheral and optical myeloneuropathy in a folic acid deficient alcoholic patient.
        Rev Neurol. 2003; 37: 726-729
        • Sadun A.A.
        Metabolic optic neuropathies.
        Semin Ophthalmol. 2002; 17: 29-32
        • Hsu C.T.
        • Miller N.R.
        • Wray M.L.
        Optic neuropathy from folic acid deficiency without alcohol abuse.
        Ophthalmologica. 2002; 216: 65-67
        • Barnouin J.
        • Perez Cristia R.
        • Chassagne M.
        • Barrios T.V.
        • Arnaud J.
        • Fleites Mestre P.
        • et al.
        Vitamin and nutritional status in Cuban smokers and nonsmokers in the context of an emerging epidemic neuropathy.
        Int J Vitam Nutr Res. 2000; 70: 126-138
      1. Epidemic optic neuropathy in Cuba — clinical characterization and risk factors.
        N Engl J Med. 1995; 333: 1176-1182
        • DeLong D.M.
        Epidemic neuropathy in Cuba.
        Ann Intern Med. 1995; 123: 734
        • Kesler A.
        • Pianka P.
        Toxic optic neuropathy.
        Curr Neurol Neurosci Rep. 2003; 3: 410-414
        • Asregadoo E.
        Blood levels of thiamine and ascorbic acid in chronic open-angle glaucoma.
        Ann Ophthalmol. 1979; 11: 1095-1100
        • Gherghel D.
        • Griffiths H.R.
        • Hilton E.J.
        • Cunliffe I.A.
        • Hosking S.L.
        Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma.
        Invest Ophthalmol Vis Sci. 2005; 46: 877-883
        • Desmettre T.
        • Rouland J.-F.
        Hypothèses sur le rôle des facteurs nutritionnels au cours des hypertonies oculaires et du glaucome.
        J Fr Ophtalmol. 2005; 28: 312-316
        • Walsh T.J.
        Blurred vision.
        in: Walsh T.J. Neuro-ophthalmology. Clinical signs and symptoms. third edition ed. Lea & Febiger, Philadelphia1992: 421-491
        • Krisovic V.
        • Vignal-Clermont C.
        • Blain P.
        • Gaudric A.
        Acute optic neuropathy in methyl alcohol intoxication: a case report.
        J Fr Ophtalmol. 2001; 24: 522-526
        • Katz B.
        The dyschromatopsia of optic neuritis: a descriptive analysis of data from the optic neuritis treatment trial.
        Trans Am Ophthalmol Soc. 1995; 93: 685-708
        • Walsh T.J.
        Visual field defects.
        in: Walsh T.J. Neuro-ophthalmology. Clinical signs and symptoms. third edition ed. Lea & Febiger, Philadelphia1992: 562-615
        • Kupersmith M.J.
        • Weiss P.A.
        • Carr R.E.
        The visual-evoked potential in tobacco–alcohol and nutritional amblyopia.
        Am J Ophthalmol. 1983; 95: 307-314
        • Lessell S.
        Nutritional amblyopia.
        J Neuroophthalmol. 1998; 18: 106-111
        • Kerrison J.B.
        • Miller N.R.
        • Hsu F.
        • Beaty T.H.
        • Maumenee I.H.
        • Smith K.H.
        • et al.
        A case-control study of tobacco and alcohol consumption in Leber hereditary optic neuropathy.
        Am J Ophthalmol. 2000; 130: 803-812
        • Cullom M.E.
        • Heher K.L.
        • Miller N.R.
        • Savino P.J.
        • Johns D.R.
        Leber's hereditary optic neuropathy masquerading as tobacco–alcohol amblyopia.
        Arch Ophthalmol. 1993; 111: 1482-1485
        • Smiddy W.E.
        • Green W.R.
        Nutritional amblyopia. A histopathologic study with retrospective clinical correlation.
        Graefes Arch Clin Exp Ophthalmol. 1987; 225: 321-324
        • Gill G.V.
        • Bell D.R.
        Persisting nutritional neuropathy amongst former war prisoners.
        J Neurol Neurosurg Psychiatry. 1982; 45: 861-865
        • Arnaud J.
        • Fleites-Mestre P.
        • Chassagne M.
        • Verdura T.
        • Garcia Garcia I.
        • Hernandez-Fernandez T.
        • et al.
        Vitamin B intake and status in healthy Havanan men, 2 years after the Cuban neuropathy epidemic.
        Br J Nutr. 2001; 85: 741-748
        • Costagliola C.
        • Cotticelli L.
        • Menzione M.
        • Rinaldi M.
        • Russo S.
        • Rinaldi E.
        Red cell reduced glutathione and tobacco smoke-induced optic neuropathy.
        Metab Pediatr Syst Ophthalmol. 1990; 13
        • Rizzo J.F.I.
        • Lessell S.
        Tobacco amblyopia.
        Am J Ophthalmol. 1993; 116: 84-87
        • Samples J.R.
        • Younge B.R.
        Tobacco–alcohol amblyopia.
        J Clin Neuroophthalmol. 1981; 1: 213-218
        • Dang C.V.
        Tobacco–alcohol amblyopia: a proposed biochemical basis for pathogenesis.
        Med Hypotheses. 1981; 7: 1317-1328
        • Wilson J.
        Cyanide in human disease: a review of clinical and laboratory evidence.
        Fundam Appl Toxicol. 1983; 3: 397-399
        • Lessell S.
        Experimental cyanide optic neuropathy.
        Arch Ophthalmol. 1971; 86: 194-204
        • Knox D.L.
        • Chen M.F.
        • Guilarte T.R.
        • Dang C.V.
        • Burnette J.
        Nutritional amblyopia: folic acid, vitamin B-12, and other vitamins.
        Retina. 1982; 2: 288-293
        • Thompson R.E.
        • Felton J.L.
        Nutritional amblyopia associated with jejunoileal bypass surgery.
        Ann Ophthalmol. 1982; 14: 848-850
        • Puvanendran K.
        • Devathasan G.
        • Wong P.K.
        Visual evoked responses in diabetes.
        J Neurol Neurosurg Psychiatry. 1983; 46: 643-647
        • Gass J.
        Diseases of the optic nerve that may simulate macular disease.
        Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1977; 83: 763-770
        • Aung T.
        • Okada K.
        • Poinoosawmy D.
        • Membrey L.
        • Brice G.
        • Child A.H.
        • et al.
        The phenotype of normal tension glaucoma patients with and without OPA1 polymorphisms.
        Br J Ophthalmol. 2003; 87: 149-152
        • Buono L.M.
        • Foroozan R.
        • Sergott R.C.
        • Savino P.J.
        Is normal tension glaucoma actually an unrecognized hereditary optic neuropathy? New evidence from genetic analysis.
        Curr Opin Ophthalmol. 2002; 13: 362-370
        • Tsao K.
        • Aitken P.A.
        • Johns D.R.
        Smoking as an aetiological factor in a pedigree with Leber's hereditary optic neuropathy.
        Br J Ophthalmol. 1999; 83: 577-581
        • Yolton D.P.
        Nutritional effects of zinc on ocular and systemic physiology.
        J Am Optom Assoc. 1981; 52: 409-414
        • DeVita E.G.
        • Miao M.
        • Sadun A.A.
        Optic neuropathy in ethambutol-treated renal tuberculosis.
        J Clin Neuroophthalmol. 1987; 7: 77-86
        • Hirayama Y.
        Histochemical localization of zinc and copper in rat ocular tissues.
        Acta Histochem. 1990; 89: 107-111
        • Elsayed N.M.
        Antioxidant mobilization in response to oxidative stress: a dynamic environmental–nutritional interaction.
        Nutrition. 2001; 17: 828-834
        • Izzotti A.
        • Bagnis A.
        • Sacca S.C.
        The role of oxidative stress in glaucoma.
        Mutat Res. 2006; 612: 105-114
        • Ferreira S.M.
        • Lerner S.F.
        • Brunzini R.
        • Evelson P.A.
        • Llesuy S.F.
        Oxidative stress markers in aqueous humor of glaucoma patients.
        Am J Ophthalmol. 2004; 137: 62-69
        • Izzotti A.
        • Di Marco B.
        • De Flora S.
        • Sacca S.
        Open angle glaucoma: epidemiology, pathogenesis and prevention.
        Recenti Prog Med. 2006; 97: 37-45
        • Krumsiek J.
        • Kruger C.
        • Patzold U.
        Tobacco–alcohol amblyopia neuro-ophthalmological findings and clinical course.
        Acta Neurol Scand. 1985; 72: 180-187