Advertisement

Strategies for the elimination of taeniasis/cysticercosis

  • Héctor H. García
    Correspondence
    Corresponding author. Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru.
    Affiliations
    Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

    Proyecto de Eliminacion de Cisticercosis, Universidad Peruana Cayetano Heredia, Lima, Peru

    Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru

    Department of International Health, Johns Hopkins University Bloomberg School of Hygiene and Public Health, Baltimore, MD, USA
    Search for articles by this author
  • Armando E. González
    Affiliations
    Proyecto de Eliminacion de Cisticercosis, Universidad Peruana Cayetano Heredia, Lima, Peru

    School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru

    Department of International Health, Johns Hopkins University Bloomberg School of Hygiene and Public Health, Baltimore, MD, USA
    Search for articles by this author
  • Oscar H. Del Brutto
    Affiliations
    Hospital-Clinica Kennedy, Guayaquil, Ecuador
    Search for articles by this author
  • Victor C.W. Tsang
    Affiliations
    Proyecto de Eliminacion de Cisticercosis, Universidad Peruana Cayetano Heredia, Lima, Peru

    Department of International Health, Johns Hopkins University Bloomberg School of Hygiene and Public Health, Baltimore, MD, USA

    Parasitic Diseases Branch, Division of Parasitic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, USA
    Search for articles by this author
  • Fernando Llanos-Zavalaga
    Affiliations
    Proyecto de Eliminacion de Cisticercosis, Universidad Peruana Cayetano Heredia, Lima, Peru

    School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru
    Search for articles by this author
  • Guillermo Gonzalvez
    Affiliations
    Proyecto de Eliminacion de Cisticercosis, Universidad Peruana Cayetano Heredia, Lima, Peru
    Search for articles by this author
  • Jaime Romero
    Affiliations
    Proyecto de Eliminacion de Cisticercosis, Universidad Peruana Cayetano Heredia, Lima, Peru
    Search for articles by this author
  • Robert H. Gilman
    Affiliations
    Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

    Proyecto de Eliminacion de Cisticercosis, Universidad Peruana Cayetano Heredia, Lima, Peru

    Department of International Health, Johns Hopkins University Bloomberg School of Hygiene and Public Health, Baltimore, MD, USA
    Search for articles by this author
  • for The Cysticercosis Working Group in Peru

      Abstract

      Advances in the field of neurocysticercosis continue to shape our understanding of the disease and our efforts to control it. Several attempts have been made to eradicate the disease with active interventions such as changing domestic pig-raising practices, mass chemotherapy of porcine cysticercosis and taeniasis, selective detection and treatment of taeniasis, and community health education. Moreover, ongoing progress in the diagnosis of taeniasis and the development of a porcine vaccine against cysticercosis in Australia, Mexico and Peru has yielded at least one effective vaccine that is currently available. Thus far, however, attempted interventions have only been successful in temporarily disrupting transmission of the disease. Controlled data on the efficacy and acceptability of the different interventions is urgently needed to provide a base-line schematic for intervention which could later be tailored to each particular endemic scenario.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Garcia H.H.
        • Del Brutto O.H.
        Neurocysticercosis: updated concepts about an old disease.
        Lancet Neurol. 2005; 4: 653-661
        • Montano S.M.
        • Villaran M.V.
        • Ylquimiche L.
        • et al.
        Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru.
        Neurology. 2005; 65: 229-233
        • Del Brutto O.H.
        • Santibanez R.
        • Idrovo L.
        • et al.
        Epilepsy and neurocysticercosis in Atahualpa: a door-to-door survey in rural coastal Ecuador.
        Epilepsia. 2005; 46: 583-587
        • Medina M.T.
        • Duron R.M.
        • Martinez L.
        • et al.
        Prevalence, incidence, and etiology of epilepsies in rural Honduras: the Salama Study.
        Epilepsia. 2005; 46: 124-131
        • Sanchez A.L.
        • Lindback J.
        • Schantz P.M.
        • et al.
        A population-based, case-control study of Taenia solium taeniasis and cysticercosis.
        Ann Trop Med Parasitol. 1999; 93: 247-258
        • Garcia-Noval J.
        • Moreno E.
        • de Mata F.
        • et al.
        An epidemiological study of epilepsy and epileptic seizures in two rural Guatemalan communities.
        Ann Trop Med Parasitol. 2001; 95: 167-175
        • Allan J.C.
        • Wilkins P.P.
        • Tsang V.C.
        • Craig P.S.
        Immunodiagnostic tools for taeniasis.
        Acta Trop. 2003; 87: 87-93
        • Wilkins P.P.
        • Allan J.C.
        • Verastegui M.
        • et al.
        Development of a serologic assay to detect Taenia solium taeniasis.
        Am J Trop Med Hyg. 1999; 60: 199-204
        • Levine M.Z.
        • Calderon J.C.
        • Wilkins P.P.
        • et al.
        Characterization, cloning, and expression of two diagnostic antigens for Taenia solium tapeworm infection.
        J Parasitol. 2004; 90: 631-638
        • Hancock K.
        • Pattabhi S.
        • Greene R.M.
        • et al.
        Characterization and cloning of GP50, a Taenia solium antigen diagnostic for cysticercosis.
        Mol Biochem Parasitol. 2004; 133: 115-124
        • Hancock K.
        • Pattabhi S.
        • Whitfield F.W.
        • et al.
        Characterization and cloning of T24, a Taenia solium antigen diagnostic for cysticercosis.
        Mol Biochem Parasitol. 2006;
        • Dorny P.
        • Brandt J.
        • Geerts S.
        Immunodiagnostic approaches for detecting Taenia solium.
        Trends Parasitol. 2004; 20 ([author reply 260-1]): 259-260
        • Garcia H.H.
        • Harrison L.J.
        • Parkhouse R.M.
        • et al.
        A specific antigen-detection ELISA for the diagnosis of human neurocysticercosis. The Cysticercosis Working Group in Peru.
        Trans R Soc Trop Med Hyg. 1998; 92: 411-414
        • Handali S.
        • Gonzalez A.E.
        • Hancock K.
        • et al.
        Porcine antibody responses to Taenia solium antigens rGp50 and sTs18var1.
        Am J Trop Med Hyg. 2004; 71: 322-326
        • Gonzalez A.E.
        • Gauci C.G.
        • Barber D.
        • et al.
        Vaccination of pigs to control human neurocysticercosis.
        Am J Trop Med Hyg. 2005; 72: 837-839
        • Flisser A.
        • Gauci C.G.
        • Zoli A.
        • et al.
        Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens.
        Infect Immun. 2004; 72: 5292-5297
        • Huerta M.
        • de Aluja A.S.
        • Fragoso G.
        • et al.
        Synthetic peptide vaccine against Taenia solium pig cysticercosis: successful vaccination in a controlled field trial in rural Mexico.
        Vaccine. 2001; 20: 262-266
        • Gonzales A.E.
        • Garcia H.H.
        • Gilman R.H.
        • et al.
        Effective, single-dose treatment or porcine cysticercosis with oxfendazole.
        Am J Trop Med Hyg. 1996; 54: 391-394
        • Gonzalez A.E.
        • Falcon N.
        • Gavidia C.
        • et al.
        Treatment of porcine cysticercosis with oxfendazole: a dose–response trial.
        Vet Rec. 1997; 141: 420-422
        • Gonzalez A.E.
        • Falcon N.
        • Gavidia C.
        • et al.
        Time-response curve of oxfendazole in the treatment of swine cysticercosis.
        Am J Trop Med Hyg. 1998; 59: 832-836
        • Schantz P.M.
        • Cruz M.
        • Sarti E.
        • Pawlowski Z.
        Potential eradicability of taeniasis and cysticercosis.
        Bull Pan Am Health Organ. 1993; 27: 397-403
        • Tsang V.
        • Wilson M.
        Taenia solium cysticercosis, an under-recognized but serious public health problem.
        Parasitol Today. 1995; : 124-126
        • Bern C.
        • Garcia H.H.
        • Evans C.
        • et al.
        Magnitude of the disease burden from neurocysticercosis in a developing country.
        Clin Infect Dis. 1999; 29: 1203-1209
        • Wallin M.T.
        • Kurtzke J.F.
        Neurocysticercosis in the United States: review of an important emerging infection.
        Neurology. 2004; 63: 1559-1564
        • Schantz P.M.
        • Tsang V.C.
        The US Centers for Disease Control and Prevention (CDC) and research and control of cysticercosis.
        Acta Trop. 2003; 87: 161-163
        • White Jr., A.C.
        Neurocysticercosis: a major cause of neurological disease worldwide.
        Clin Infect Dis. 1997; 24 ([quiz 114-5]): 101-113
        • Flisser A.
        • Madrazo I.
        • Plancarte A.
        • et al.
        Neurological symptoms in occult neurocysticercosis after single taeniacidal dose of praziquantel.
        Lancet. 1993; 342: 748
        • Schantz P.M.
        • Sarti E.
        • Plancarte A.
        • et al.
        Community-based epidemiological investigations of cysticercosis due to Taenia solium: comparison of serological screening tests and clinical findings in two populations in Mexico.
        Clin Infect Dis. 1994; 18: 879-885
        • Garcia H.H.
        • Gilman R.H.
        • Gonzalez A.E.
        • et al.
        Hyperendemic human and porcine Taenia solium infection in Peru.
        Am J Trop Med Hyg. 2003; 68: 268-275
        • Gonzalez A.E.
        • Cama V.
        • Gilman R.H.
        • et al.
        Prevalence and comparison of serologic assays, necropsy, and tongue examination for the diagnosis of porcine cysticercosis in Peru.
        Am J Trop Med Hyg. 1990; 43: 194-199
        • Cruz M.
        • Davis A.
        • Dixon H.
        • Pawlowski Z.S.
        • Proano J.
        Operational studies on the control of Taenia solium taeniasis/cysticercosis in Ecuador.
        Bull World Health Organ. 1989; 67: 401-407
        • Keilbach N.M.
        • de Aluja A.S.
        • Sarti-Gutierrez E.
        A programme to control taeniasis-cysticercosis (T. solium): experiences in a Mexican village.
        Acta Leiden. 1989; 57: 181-189
        • Sarti E.
        • Schantz P.M.
        • Avila G.
        • Ambrosio J.
        • Medina-Santillan R.
        • Flisser A.
        Mass treatment against human taeniasis for the control of cysticercosis: a population-based intervention study.
        Trans R Soc Trop Med Hyg. 2000; 94: 85-89
        • Allan J.C.
        • Velasquez-Tohom M.
        • Fletes C.
        • et al.
        Mass chemotherapy for intestinal Taenia solium infection: effect on prevalence in humans and pigs.
        Trans R Soc Trop Med Hyg. 1997; 91: 595-598
        • Garcia H.H.
        • Gonzalez A.E.
        • Gilman R.H.
        • et al.
        Combined human and porcine mass chemotherapy for the control of T. solium.
        Am J Trop Med Hyg. 2006; 74: 850-855
        • Molinari J.L.
        • Rodriguez D.
        • Tato P.
        • Soto R.
        • Arechavaleta F.
        • Solano S.
        Field trial for reducing porcine Taenia solium cysticercosis in Mexico by systematic vaccination of pigs.
        Vet Parasitol. 1997; 69: 55-63
        • Molinari J.L.
        • Soto R.
        • Tato P.
        • et al.
        Immunization against porcine cysticercosis in an endemic area in Mexico: a field and laboratory study.
        Am J Trop Med Hyg. 1993; 49: 502-512
        • de Aluja A.S.
        • Villalobos N.M.
        • Nava G.
        • et al.
        Therapeutic capacity of the synthetic peptide-based vaccine against Taenia solium cysticercosis in pigs.
        Vaccine. 2005; 23: 4062-4069
        • Sarti E.
        • Flisser A.
        • Schantz P.
        • Bronfman M.
        • Wijeyaratne P.
        Intervention strategies for the prevention and control of Taenia solium taeniosis and cysticercosis in rural areas of Mexico.
        in: Garcia H.H. Martinez S.M. Taenia solium Taeniasis/Cysticercosis. Lima: Ed. Universo, 1999: 327-338
        • Lightowlers M.W.
        Vaccination for the prevention of cysticercosis.
        Dev Biol (Basel). 2004; 119: 361-368
        • Wang Q.M.
        • Sun S.H.
        • Hu Z.L.
        • Wu D.
        • Wang Z.C.
        Immune response and protection elicited by DNA immunisation against Taenia cysticercosis.
        Vaccine. 2003; 21: 1672-1680
        • Guo A.
        • Jin Z.
        • Zheng Y.
        • et al.
        Induction of protection against porcine cysticercosis in growing pigs by DNA vaccination.
        Vaccine. 2006;
        • Fan P.C.
        • Ma Y.X.
        • Kuo C.H.
        • Chung W.C.
        Survival of Taenia solium cysticerci in carcasses of pigs kept at 4 C.
        J Parasitol. 1998; 84: 174-175
        • Sotelo J.
        • Rosas N.
        • Palencia G.
        Freezing of infested pork muscle kills cysticerci.
        Jama. 1986; 256: 893-894
        • Verster A.
        • Du Plessis T.A.
        • Van Den Heever L.W.
        The effect of gamma radiation on the cysticerci of Taenia solium.
        Onderstepoort J Vet Res. 1976; 43: 23-26