Abstract
Puerperal cerebral veno-sinus thrombosis (PCVT) is a common form of stroke in young
women in India, which is associated with high morbidity and mortality. The frequency
of PCVT in India is 10 to 12 times more compared to western population. As yet, the
etiology of this condition is unclear. Our aim was to study the prevalence and the
role of the common genetic polymorphisms associated with thrombophilia such as factor
V Leiden, prothrombin G20210A and methylene tetrahydrofolate reductase (MTHFR) C677T,
in aseptic PCVT. We investigated 86 women with PCVT and 86 age-matched women with
no post-partum complications. Polymerase chain reaction (PCR)/restriction fragment
length polymorphism analysis was used to identify their genotypes. The frequency of
the three polymorphisms in cases and controls were: factor V Leiden, 2.3% versus 1.2%
(OR 0.49, 95% CI=0.02–7.12, p=1.000) and MTHFR C677T, 16.3% versus 17.4% (OR 0.92, 95% CI=0.39–2.19, p=0.838). The prothrombin G20210A variant was not detected in either patients or controls.
The clinical characteristics of the PCVT patients with the polymorphisms did not differ
significantly from those without them. In our series of PCVT patients, the risk associated
with the established thrombophilic risk factors is insignificant. Exploration of these
gene polymorphisms seems to be of limited value in the investigation of PCVT in south
Indian women.
Keywords
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Article info
Publication history
Accepted:
May 26,
2006
Received in revised form:
May 25,
2006
Received:
February 22,
2006
Identification
Copyright
© 2006 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
