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Research Article| Volume 249, ISSUE 1, P19-24, November 01, 2006

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Dengue infection: neurological manifestations and cerebrospinal fluid (CSF) analysis

  • C.N. Soares
    Correspondence
    Corresponding authors. Soares is to be contacted at Rua Aureliano Coutinho 81/605, 25625 000 Rio de Janeiro, Brazil. Tel.: +55 21 98524686. Puccioni-Sohler, Rua Dezenove de Fevereiro 185/705, 22280 030 Rio de Janeiro, Brazil. Fax: +55 21 25574731.
    Affiliations
    Neurology Service, HUAP/UFF (Hospital Universitário Antônio Pedro/Universidade Federal Fluminense), Niterói, RJ, Brazil

    CSF Laboratory, Clinical Pathology Service, HUCFF/UFRJ (Hospital Universitário Clementino Fraga Filho/ Universidade Federal do Rio de Janeiro), RJ, Brazil
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  • L.C. Faria
    Affiliations
    CSF Laboratory, Clinical Pathology Service, HUCFF/UFRJ (Hospital Universitário Clementino Fraga Filho/ Universidade Federal do Rio de Janeiro), RJ, Brazil
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  • J.M. Peralta
    Affiliations
    Microbiology Institute, CCS/UFRJ (Universidade Federal do Rio de Janeiro), RJ, Brazil
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  • M.R.G. de Freitas
    Affiliations
    Neurology Service, HUAP/UFF (Hospital Universitário Antônio Pedro/Universidade Federal Fluminense), Niterói, RJ, Brazil
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  • M. Puccioni-Sohler
    Correspondence
    Corresponding authors. Soares is to be contacted at Rua Aureliano Coutinho 81/605, 25625 000 Rio de Janeiro, Brazil. Tel.: +55 21 98524686. Puccioni-Sohler, Rua Dezenove de Fevereiro 185/705, 22280 030 Rio de Janeiro, Brazil. Fax: +55 21 25574731.
    Affiliations
    CSF Neurolife Laboratory, Rio de Janeiro, RJ, Brazil

    CSF Laboratory, Clinical Pathology Service, HUCFF/UFRJ (Hospital Universitário Clementino Fraga Filho/ Universidade Federal do Rio de Janeiro), RJ, Brazil

    Neurology Service, HUGG/UNIRIO (Hospital Universitário Gaffree Guinle/ Universidade Federal do Estado do Rio de Janeiro), RJ, Brazil
    Search for articles by this author

      Abstract

      Neurological manifestation is considered a rare complication of dengue infection. Neurological and cerebrospinal fluid (CSF) findings of 13 patients with dengue infection were studied. Seven patients had encephalitis, two had myelitis and four showed Guillain-Barré syndrome (GBS). No alteration in CSF was found from 57% of those with encephalitis. Patients with GBS and myelitis showed a CSF–blood barrier dysfunction. The differences in the CSF may be related to the location of the lesion and multiple mechanisms of the disease in the nervous system.

      Keywords

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