Abstract
Aim
Due of paucity of studies on stress ulcer prophylaxis in intracerebral hemorrhage
(ICH), we have evaluated the usefulness of ranitidine and sucralfate in preventing
gastric hemorrhage (GH) in patients with ICH.
Subjects and methods
In a hospital-based randomized placebo-controlled study, patients with CT-proven ICH
within 7 days of ictus were randomized into ranitidine 50 mg i.v. eight hourly, sucralfate
1 g six hourly and placebo groups. Patients were conservatively managed. Primary endpoint
was occurrence of GH within 15 days of ictus and secondary endpoint 1-month mortality.
Results
The mean age of the patients was 57.2 (range 25–90) years and 40 were females. There
were 45 patients in ranitidine, 49 in sucralfate and 47 in placebo group. Demographic,
clinical and radiological features were not significantly different in 3 groups. GH
occurred in 11 (23.4%) patients in placebo, 5 (11.1%) in ranitidine and 7 (14.3%)
in sucralfate group, which was not significant. Only one female had GH. There were
13 (27.7%) deaths in placebo, 5 (11.1%) in ranitidine and 12 (24.5%) in sucralfate
group. Pneumonia occurred in placebo group in 5 (10.6%), ranitidine in 2 (4.4%) and
sucralfate in 5 (10.2%) patients, which was not significantly different.
Conclusion
Ranitidine and sucralfate do not seem to significantly prevent GH or reduce 1-month
mortality.
Keywords
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Article Info
Publication History
Accepted:
July 10,
2005
Received in revised form:
July 8,
2005
Received:
September 20,
2004
Identification
Copyright
© 2005 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
