Abstract
We investigated whether brain SPECT findings show any differences between patients
with mild and moderate Alzheimer's disease (AD) and to compare results with event
related potentials (ERPs). Twenty-two patients with mild to moderate AD diagnosed
according to NINCDS-ADRDA criteria and 10 age-matched control subjects were included
in this prospective study. All subjects underwent ERP recordings and Tc-99m HMPAO
brain SPECT study. Cortical perfusion index (CPI) was calculated as the ratio of cortical
activity to the cerebellum activity. CPI was found to be statistically lower in bilaterally
posterolateral temporal cortex and precuneus in the moderate AD compared to the control
group. There was no statistically significant difference between the mild AD and control
groups for CPI in any cortical areas. The mean P300 latency was statistically prolonged
in the mild and moderate AD compared to the control group. In addition, in moderate
AD P300 latency was longer than in mild AD. While the mean P300 amplitude was statistically
reduced in moderate AD compared to the control and mild AD, there was no statistically
significant difference between the mild AD and control groups. There was a strong
negative correlation between P300 latency and CPI in the right and left precuneus
in the moderate AD group. The present study suggested that Tc-99m HMPAO SPECT study
is the more appropriate technique for patients with moderate AD rather than mild AD.
Our results indicated that alterations in ERPs, especially prolongation of P300 latency
could be a finding that occurred earlier than the deterioration in cerebral blood
flow. We thought that precuneus is closely related to cognitive function and may have
an important role in the pathophysiology of AD.
Keywords
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Article info
Publication history
Accepted:
March 8,
2005
Received in revised form:
January 7,
2005
Received:
October 22,
2004
Footnotes
☆This study was presented at the Annual Congress of the European Association of Nuclear Medicine in Finland, Helsinki (4–8 September 2004).
Identification
Copyright
© 2005 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
