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Cortical lesions and brain atrophy in MS

      Abstract

      Multiple sclerosis is generally considered a disease of the white matter. However, this is only one pathological aspect of the disease as demyelination is prominent in the grey matter of deep cerebral nuclei and the cerebral cortex. In this review, we discuss the possibility that disease involvement of grey matter structures may significantly contribute to clinical disability in multiple sclerosis patients.

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      References

        • Confavreux C.
        • Vukusic S.
        • Moreau T.
        • Adeleine P.
        Relapses and progression of disability in multiple sclerosis.
        N Engl J Med. 2000; 343: 1430-1438
        • Ebers G.C.
        Natural history of multiple sclerosis.
        J Neurol Neurosurg Psychiatry. 2001; 71: ii16-ii19
        • Ebers G.C.
        Chapter 6: the natural history of MS.
        in: Paty D.W. Ebers G.C. Multiple sclerosis. FA Davis and Co, Philadelphia1998
        • Weinshenker B.G.
        • Bass B.
        • Rice G.P.
        • Noseworthy J.
        • Carriere W.
        • Baskerville J.
        • et al.
        Natural history of multiple sclerosis: a geographically based study: 1. Clinical course and disability.
        Brain. 1989; 112: 133-146
        • Cottrell D.A.
        • Kremenchutzky M.
        • Rice G.P.A.
        • Koopman W.J.
        • Hader W.
        • Baskerville J.
        • et al.
        The natural history of multiple sclerosis: a geographically based study: 5. The clinical features and natural history of primary progressive multiple sclerosis.
        Brain. 1999; 122: 625-639
        • Thompson A.J.
        • Polman C.H.
        • Miller D.H.
        • McDonald W.I.
        • Brochet B.
        • Filippi M.
        • et al.
        Primary progressive multiple sclerosis.
        Brain. 1997; 120: 1085-1096
        • Goodin D.S.
        • Frohman E.M.
        • Garmany G.P.
        • Halper J.
        • Likosky W.H.
        • Lublin F.D.
        • et al.
        Disease modifiying therapies in multiple sclerosis: report of the therapeutics and technology assessment subcommittee of the American academy of neurology and the MS council for clinical practice guidelines.
        Neurology. 2002; 58: 169-178
        • Leary S.M.
        • Miller D.H.
        • Stevenson V.L.
        • Brex P.A.
        • Chard D.T.
        • Thompson A.J.
        Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial.
        Neurology. 2003; 60: 44-51
        • Thompson A.J.
        • Montalban X.
        • Barkhof F.
        • Brochet B.
        • Filippi M.
        • Miller D.H.
        • et al.
        Diagnostic criteria for primary progressive multiple sclerosis: a position paper.
        Ann Neurol. 2000; 47: 831-835
        • Thompson A.J.
        • Kermode A.G.
        • Wicks D.
        • MacManus D.G.
        • Kendall B.E.
        • Kingsley D.P.
        • et al.
        Major differences in the dynamics of primary and secondary progressive multiple sclerosis.
        Ann Neurol. 1991; 29: 53-62
        • Stevenson V.L.
        • Smith S.M.
        • Matthews P.M.
        • Miller D.H.
        • Thompson A.J.
        Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophy.
        J Neurol. 2002; 249: 171-177
        • Brex P.A.
        • Ciccarelli O.
        • O'Riordan J.I.
        • Sailer M.
        • Thompson A.J.
        • Miller D.H.
        A longitudinal study of abnormalities on MRI and disability from multiple sclerosis.
        N Engl J Med. 2002; 346: 158-164
        • Ingle G.T.
        • Thompson A.J.
        • Miller D.H.
        Magnetic resonance imaging in primary progressive multiple sclerosis.
        J Rehabil Res Dev. 2002; 39: 261-271
        • Prineas J.W.
        • Kwon E.E.
        • Cho E.S.
        • Sharer L.R.
        • Barnett M.H.
        • Oleszak E.L.
        • et al.
        Immunopathology of secondary-progressive multiple sclerosis.
        Ann Neurol. 2001; 50: 646-657
        • Brück W.
        • Lucchinetti C.
        • Lassmann H.
        The pathology of primary progressive multiple sclerosis.
        Mult Scler. 2002; 8: 93-97
        • Rovaris M.
        • Bozzali M.
        • Iannucci G.
        • Ghezzi A.
        • Caputo D.
        • Montanari E.
        • et al.
        Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: a diffusion-tensor magnetic resonance imaging study.
        Arch Neurol. 2002; 59: 1406-1412
        • Prineas J.W.
        The neuropathology of multiple sclerosis.
        in: Koetsier J.C. Handbook of clinical neurology. Demyelinating disease. vol 3. Elsevier, Amsterdam1985: 213-257
        • Trapp B.D.
        • Peterson J.
        • Ransohoff R.M.
        • Rudick R.
        • Mork S.
        • Bo L.
        Axonal transection in the lesions of multiple sclerosis.
        N Engl J Med. 1998; 338: 278-285
        • Kornek B.
        • Lassmann H.
        Axonal pathology in multiple sclerosis. A histotical note.
        Brain Pathol. 1999; 9: 651-656
        • Bitsch A.
        • Schuchardt J.
        • Bunkowski S.
        • Kuhlmann T.
        • Brück W.
        Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation.
        Brain. 2000; 123: 1174-1183
        • Johnson A.J.
        • Upshaw J.
        • Pavelko K.P.
        • Rodriguez M.
        • Pease L.R.
        Preservation of motor function by inhibition of CD8(+) virus peptide-specific T-cells in Theiler's virus infection.
        FASEB J. 2001; 15: 2760-2762
        • Medana I.
        • Martinic M.A.
        • Wekerle H.
        • Neumann H.
        Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes.
        Am J Pathol. 2001; 159: 809-815
        • Jellinger K.
        Einige morphologische Aspekte der Multiplen Sklerose.
        Wien. Z. Nervenheilkd. 1969; : 12-37
        • Dalton C.M.
        • Brex P.A.
        • Jenkins R.
        • Fox N.C.
        • Miszkiel K.M.
        • Crum W.R.
        • et al.
        Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis.
        J Neurol Neurosurg Psychiatry. 2002; 73: 141-147
        • Chard D.T.
        • Griffin C.M.
        • Parker G.J.M.
        • Kapoor R.
        • Thompson A.J.
        • Miller D.H.
        Brain atrophy in clinically early relapsing–remitting multiple sclerosis.
        Brain. 2002; 125: 327-337
        • De Stefano N.
        • Matthews P.M.
        • Filippi M.
        • Agosta F.
        • De Luca M.
        • Bartolozzi M.L.
        • et al.
        Evidence of early cortical atrophy in MS: relevance to white matter changes and disability.
        Neurology. 2003; 60: 1157-1162
        • Simon J.H.
        • Jacobs L.D.
        • Campion M.K.
        • Rudick R.A.
        • Cookfair D.L.
        • Herndon R.M.
        • et al.
        A longitudinal study of brain atrophy in relapsing multiple sclerosis.
        Neurology. 1999; 53: 139-148
        • Kalkers N.F.
        • Bergers L.
        • Castelijns J.A.
        • van Walderveen M.A.A.
        • Bot J.C.J.
        • Ader H.J.
        • et al.
        Optimizing the association between disability and biological markers in MS.
        Neurology. 2001; 57: 1253-1257
        • Lin X.
        • Tench C.R.
        • Turner B.
        • Blumhardt L.D.
        • Constantinescu C.S.
        Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial.
        J Neurol Neurosurg Psychiatry. 2003; 74: 1090-1094
        • Stevenson V.L.
        • Miller D.H.
        • Leary S.M.
        • Rovaris M.
        • Barkhof F.
        • Brochet B.
        • et al.
        One year follow up study of primary and transitional progressive multiple sclerosis.
        J Neurol Neurosurg Psychiatry. 2000; 68: 713-718
        • Ingle G.T.
        • Stevenson V.L.
        • Miller D.H.
        • Thompson A.J.
        Primary progressive multiple sclerosis: a 5-year clinical and MR study.
        Brain. 2003; 126: 2528-2536
        • Thompson A.J.
        • Kermode A.G.
        • MacManus D.G.
        • Kingsley D.P.
        • Kendall B.E.
        • Moseley I.F.
        • et al.
        Pathogenesis of progressive multiple sclerosis.
        Lancet. 1989; 333: 1322-1323
        • Taylor E.W.
        Zur pathologischen Anatomie der multiplen Sklerose.
        Dtsch. Z. Nervenheilkd. 1892; 5: 1-26
        • Sander M.
        Hirnrindenbefunde bei multipler Sklerose.
        Monatsschr. Psychiatr. Neurol. 1898; : 427-436
        • Dinkler
        Zur Kasuistik der multiplen Herdsklerose des Gehirns und Rückenmarks.
        Dtsch. Z. Nervenheilkd. 1904; 26: 233-247
        • Dawson J.W.
        The histology of multiple sclerosis.
        Trans R Soc Edinb. 1916; : 517-740
        • Greenfield J.G.
        • King L.S.
        Observations on the histopathology of the cerebral lesions in disseminated sclerosis.
        Brain. 1936; 59: 445-458
        • Lumsden C.E.
        The neuropathology of multiple sclerosis.
        in: Vinken P.J. Bruyn G.W. Handbook of clinical neurology. Elsevier, Amsterdam1970: 217-309
        • Brownell B.
        • Hughes J.T.
        Distribution of plaques in the cerebrum in multiple sclerosis.
        J Neurol Neurosurg Psychiatry. 1962; 25: 315-320
        • Kidd D.
        • Barkhof F.
        • McConnell R.
        • Algra P.R.
        • Allen I.V.
        • Revesz T.
        Cortical lesions in multiple sclerosis.
        Brain. 1999; 122: 17-26
        • Filippi M.
        Multiple sclerosis: a white matter disease with associated gray matter damage.
        J Neurol Sci. 2001; 185: 3-4
        • Trapp B.
        • Ransohoff R.M.
        • Fisher E.
        • Rudick R.A.
        Neurodegeneration in multiple sclerosis: relationship to neurological disability.
        Neuroscientist. 1999; 5: 48-57
        • Peterson J.W.
        • Bö L.
        • Mörk S.
        • Chang A.
        • Trapp B.
        Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions.
        Ann Neurol. 2001; 50: 389-400
        • Bo L.
        • Vedeler C.A.
        • Nyland H.I.
        • Trapp B.D.
        • Mork S.J.
        Subpial demyelination in the cerebral cortex of multiple sclerosis patients.
        J Neuropathol Exp Neurol. 2003; 62: 723-732
        • Cercignani M.
        • Bozzali M.
        • Iannucci G.
        • Comi G.
        • Filippi M.
        Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis.
        J Neurol Neurosurg Psychiatry. 2001; 70: 311-317
        • Reddy H.
        • Narayanan S.
        • Arnoutelis R.
        • Jenkinson M.
        • Antel J.
        • Matthews P.M.
        • et al.
        Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis.
        Brain. 2000; 123: 2314-2320
        • Rocca M.A.
        • Falini A.
        • Colombo B.
        • Scotti G.
        • Comi G.
        • Filippi M.
        Adaptive functional changes in the cerebral cortex of patients with nondisabling multiple sclerosis correlate with the extent of brain structural damage.
        Ann Neurol. 2002; 51: 330-339
        • Sarchielli P.
        • Presciutti O.
        • Tarducci R.
        • Gobbi G.
        • Alberti A.
        • Pelliccioli G.P.
        • et al.
        Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis.
        J Neurol. 2002; 249: 902-910
        • Bakshi R.
        • Dmochowski J.
        • Shaikh Z.A.
        • Jacobs L.
        Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients.
        J Neurol Sci. 2001; 185: 19-26
        • Lee M.
        • Reddy H.
        • Johansen-Berg H.
        • Pendlebury S.
        • Jenkinson M.
        • Smith S.
        • et al.
        The motor cortex shows adaptive functional changes to brain injury from multiple sclerosis.
        Ann Neurol. 2000; 47: 606-613
        • Staffen W.
        • Mair A.
        • Zauner H.
        • Unterrainer J.
        • Niederhofer H.
        • Kutzelnigg A.
        • et al.
        Cognitive function and fMRI in patients with multiple sclerosis: evidence for compensatory cortical activation during an attention task.
        Brain. 2002; 125: 1275-1282
        • Rao S.M.
        • Leo G.J.
        • Bernardin L.
        • Unverzagt F.
        Cognitive dsyfunction in multiple sclerosis: I. Frequency, patterns and prediction.
        Neurology. 1991; 41: 685-691
        • Rao S.M.
        • Leo G.J.
        • Ellington L.
        • Nauertz T.
        • Bernardin L.
        • Unverzagt F.
        Cognitive dysfunction in multiple sclerosis: II. Impact on employment and social functioning.
        Neurology. 1991; 41: 692-696
        • Kujala P.
        • Portin R.
        • Ruutiainen J.
        The progress of cognitive decline in multiple sclerosis. A controlled 3-year follow-up.
        Brain. 1997; 120: 289-297
        • Brooks D.J.
        • Leenders K.L.
        • Head G.
        • Marshall J.
        • Legg N.J.
        • Jones T.
        Studies on regional cerebral oxygen utilisation and cognitive function in multiple sclerosis.
        J Neurol Neurosurg Psychiatry. 1984; 47: 1182-1191
        • Ghezzi A.
        • Montanini R.
        • Basso P.F.
        • Zaffaroni M.
        • Massimo E.
        • Cazzullo C.L.
        Epilepsy in multiple sclerosis.
        Eur Neurol. 1990; 30: 218-223
        • Thompson A.J.
        • Kermode A.G.
        • Moseley I.F.
        • MacManus D.G.
        • McDonald W.I.
        Seizurs due to multiple sclerosis: seven patients with MRI correlations.
        J Neurol Neurosurg Psychiatry. 1993; 56: 1317-1320
        • Bo L.
        • Vedeler C.A.
        • Nyland H.
        • Trapp B.D.
        • Mork S.J.
        Intracortical multiple sclerosis lesions are not associated with increased lympocyte infiltration.
        Mult Scler. 2003; 9: 323-331
        • Rossolimo G.
        Zur Frage über die multiple Sklerose und Gliose. Nebst einer Bemerkung über die Vascularistionsverhältnisse der Medulla oblongata.
        Dtsch. Z. Nervenheilkd. 1897; XI: 88-121
        • Fog T.
        Topographic distribution of plaques in the spinal cord in multiple sclerosis.
        Arch Neurol Psychiatry. 1950; 63: 382-414
        • Bakshi R.
        • Ariyaratana S.
        • Benedict R.H.
        • Jacobs L.
        Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions.
        Arch Neurol. 2001; 58: 742-748
        • Barkhof F.
        The clinico-radiological paradox in multiple sclerosis revisited.
        Curr Opin Neurol. 2002; 15: 239-245