Abstract
Depressive symptoms may influence neuropsychological functioning negatively. A substantial
proportion of multiple sclerosis (MS) patients exhibit neuropsychological impairments
and depressive symptomatology is more common in MS as compared to healthy controls
and to other neurological diseases. The objectives of the present study were to assess
information processing speed, working memory and executive functions in early phase
MS and to investigate whether severity of depressive symptoms account for these aspects
of cognition in MS. The patients show slowed information processing speed and impaired
working memory, whereas executive functioning, as measured with the Wisconsin Card
Sorting Test, is unaffected. Depressive symptoms account for slowed information processing
speed, but not for impaired working memory.
Keywords
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Article info
Publication history
Accepted:
October 20,
2003
Received in revised form:
October 16,
2003
Received:
June 23,
2003
Identification
Copyright
© 2003 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
