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Research article| Volume 119, ISSUE 1, P65-73, October 1993

Further impairment of muscle phosphate kinetics by lengthening exercise in DMD/BMD carriers

An in vivo 31P-NMR spectroscopy study
DOI:https://doi.org/10.1016/0022-510X(93)90192-2
Further impairment of muscle phosphate kinetics by lengthening exercise in DMD/BMD carriers
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      Abstract

      We used phosphorus magnetic resonance spectroscopy (31P-MRS) to study the effect of exercise-induced muscle injury in the calf muscle of 7 DMD/BMD carriers and 6 non-carrier females. All subjects performed 50–80 lengthening contractions with the right calf muscles. 48 h after lengthening exercise non-carriers showed increased sensitivity to pressure in their gastrocnemius accompanied by increased T2 relaxation times and by elevated Math Eq ratios at rest. DMD/BMD carriers did not show any effect of lengthening exercise on these measurements. In-magnet exercise revealed in all carriers a reduced initial rate of Pi recovery and an increased time to fully recover the resting value of intracellular pH. Lengthening exercise further decreased the initial rate of Pi recovery. Non-carriers did not show any variation attributable to lengthening exercise either during in-magnet work or during recovery from exercise. We found that lengthening exercise contractions causes: (1) less muscle injury in carriers compared to non-carriers, (2) even slower rate of Pi recovery, but (3) no effect on Pi recovery in non-carriers. The use of lengthening exercise and measurements of Pi recovery may be a useful method to evaluate the disease process in DMD/BMD.

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      Article info

      Publication history

      Accepted: April 23, 1993
      Received in revised form: April 12, 1993
      Received: January 25, 1993

      Identification

      DOI: https://doi.org/10.1016/0022-510X(93)90192-2

      Copyright

      © 1993 Published by Elsevier Inc.

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