This paper is only available as a PDF. To read, Please Download here.
Pathological change of the globus pallidus (GP) in 6 cases of Huntington's disease (HD) was examined histometrically by comparison with 10 normal control cases. All but 1 case of HD were in late stages of the disease. Total neuronal count, area of GP, and neuronal cell density were measured in 5 selected regions of coronal sections taken along the antero-posterior axis. Contrary to the findings of previous reports, no neuronal depletion was recognized in HD in any region despite marked atrophy of tissue bulk. The atrophy was more severe in the external segment (GPe) than in the internal segment (GPi). Reactive astrocytosis and fibrillary gliosis were observed in the atrophic lesions. These results indicate that atrophy of the GP can be attributed to striato-pallidal fiber loss and not to neuronal depletion even in the late stages. These findings support the hypothesis that loss of striato-GPe fibers plays the most important role in choreic movements in HD. It remains to be determined whether the pallidal neurons are also preserved in the end stage of the disease.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of the Neurological Sciences
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The functional anatomy of basal ganglia disorders.Trends Neurosci. 1989; 12: 366-375
- Striatal and nigral neuron subpopulations in rigid Huntington's disease: implications for the functional anatomy of chorea and rigidity-akinesia.Ann. Neurol. 1990; 27: 357-365
- Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease.Ann. Neurol. 1992; 31: 425-430
- Functional architecture of basal ganglia circuits: neural substrates of parallel processing.Trends Neurosci. 1990; 13: 266-271
- Chorea and myoclonus in the monkey induced by gamma-aminobutyric acid antagonism in the lentiform complex.Brain. 1988; 111: 1211-1233
- A cytometric study of the putamen in different types of Huntington's chorea.in: Advances in Neurology. Vol. 1. Raven Press, New York1973: 369-385
- Pathologic changes in Huntington's chorea with special references to the corpus striatum.Arch. Neurol. Psychiat. 1927; 18: 867-943
- Huntinton's chorea: a pathological study.in: Advances in Neurology. Vol. 1. Raven Press, New York1973: 453-470
- Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease.Science. 1985; 227: 770-773
- Neurotransmitters and neuromodulators in the basal ganglia.Trends Neurosci. 1990; 13: 244-254
- A polymorphic DNA marker genetically linked to Huntinton's disease.Nature. 1983; 306: 234-238
- Ein Beitrag zur Huntingtonschen Erkrankung.Z. Gesamte Neurol. Psychiatr. 1938; 160: 563-597
- Morphometric studies of the neuropathological changes in choreatic diseases.J. Neurol. Sci. 1976; 28: 401-425
- Huntington's disease: pathogenesis and management.N. Engl. J. Med. 1986; 315: 1267-1276
- Fiber connections of the corpus striatum of the monkey and baboon.J. Comp. Neurol. 1945; 82: 169-204
- Striatal inhomogeneities and basal ganglia function.Movem. Disord. 1986; 1: 3-15
- The patterns of neurotransmitter and neuropeptide co-occurrence among striatal neurons.Brain Res. Rev. 1990; 15: 251-265
- Differential loss of striatal projection neurons in Huntington disease.in: Proc. Natl. Acad. Sci. USA. 85. 1988: 5733-5737
- Neuropathology of Huntington's chorea.in: Handbook of Clinical Neurology. Vol. 5. Elsevier, Amsterdam1986: 315-326
- Die anatomische Krankheitsforschung am Beispiel einer Huntingtonschen Chorea mit Wilsonschem Symptomenbild.Z. Gesamte Neurol. Psychiatr. 1926; 101: 701-728
- Neuropathological classification of Huntington's disease.J. Neuropathol. Exp. Neurol. 1985; 44: 559-577
Accepted: March 14, 1993
Received in revised form: December 18, 1992
Received: August 24, 1992
© 1993 Published by Elsevier Inc.