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Research Article| Volume 78, ISSUE 1, P17-28, March 1987

Intrathecal complement activation in neurological diseases evaluated by analysis of the terminal complement complex

DOI:https://doi.org/10.1016/0022-510X(87)90074-8
Intrathecal complement activation in neurological diseases evaluated by analysis of the terminal complement complex
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      Abstract

      The terminal complement complex (TCC) was determined in plasma and cerebrospinal fluid (CSF) from 208 neurological patients. Elevated CSF TCC levels were observed in higher frequencies in patients with infectious diseases (80%), radiculoneuritis (62%), multiple sclerosis (30%), and miscellaneous autoimmune diseases (27%) than in patients with miscellaneous non-inflammatory diseases (2–13%). The plasma level of TCC was significantly increased only in the infectious group. No positive correlation was observed between the plasma and the CSF TCC concentration in the whole patient population nor in subgroups divided according to blood-brain barrier function. Furthermore, the CSF TCC concentration did not correlate with the serum/CSF albumin ratio or with CSF total protein concentration when this was below 1.0 g/l. It is concluded that an elevated TCC concentration in CSF reflects intrathecal complement activation and that quantification of TCC in CSF may be a valuable supplement in the examination of neurological diseases.

      Keywords

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      Article info

      Publication history

      Accepted: September 9, 1986
      Received in revised form: September 8, 1986
      Received: July 8, 1986

      Footnotes

      ☆This work was financially supported by grants from the Norwegian Women's Health Organization, The Norwegian MS society, The Oslo Multiple Sclerosis Society, Fritz and Ingrid Nilsen's legacy for MS research, the Old Fellow Society, and by Mr. Pål Stenberg, Oslo.

      Identification

      DOI: https://doi.org/10.1016/0022-510X(87)90074-8

      Copyright

      © 1987 Published by Elsevier Inc.

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