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Abstract
The ability of α-MSH to facilitate the recovery of sensorimotor nerve function following
crush lesion is restricted to a critical period following such a lesion. This period
coincided with the initiation of sprouting and the disappearance of the 150 kD neurofilament
protein from the degenerating distal stump of the nerve.
Degenerating nerve contains a factor that is active in a bioassay system for MSH.
This factor could not be detected in control nerves.
The hypothesis is forwarded that a neurotrophic factor known to be present in degenerating
nerve stumps is an α-MSH-like peptide formed by the breakdown of the 150 kD neurofilament
protein.
Keywords
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References
- The fate of axonal debris in Wallerian degeneration of rat optic and sciatic nerves.J. Neuropath. Exp. Neurol. 1981; 40: 537-550
- Effects of corticotrophin (ACTH) on recovery of sensorimotor function in the rat — Structure-activity study.Europ. J. Pharmacol. 1981; 76: 73-79
- Ultrastructural study of effect of ACTH4–10 on nerve regeneration — Axons become larger in number and smaller in diameter.Acta Neuropath. (Berl.). 1983; 62: 24-30
- Stimulation by ACTH4–10 of nerve fiber regeneration following sciatic nerve crush.Muscle and Nerve. 1983; 6: 104-112
- The enhanced recovery of sensorimotor function in rats is related to the melanotropic moiety of ACTH/MSH neuropeptides.Europ. J. Pharmacol. 1983; 92: 231-236
- Neurotrophic factors and regeneration in the peripheral nervous system — A review.Psychoneuroendocrinol. 1984; (In press)
- Neurofilaments contain α-melanocyte-stimulating hormone (α-MSH)-like immunoreactivity.in: Proc. Nat. Acad. Sci. (USA). 80. 1983: 6408-6412
- A new in vitro melanophore bioassay for MSH using tail-fins of Xenopus tadpoles.Mol. Cell. Endocrinol. 1983; 32: 271-284
- Protein measurement with the Folin phenol reagent.J. Biol. Chem. 1951; 193: 265-275
- An in vivo assay of neurotropic activity.Brain Res. 1983; 278: 229-231
- The loss of neuron-specific proteins during the course of Wallerian degeneration of optic and sciatic nerve.J. Neurosci. 1981; 1: 461-470
- ACTH accelerates recovery of neuromuscular function following crushing of peripheral nerve.Peptides. 1980; 1: 135-138
- LPH, ACTH, MSH and motor systems.Pharmac. Ther. 1980; 11: 509-533
- Stimulation of intrauterine growth in rat by α-melanocytestimulating hormone.J. Endocrinol. 1976; 70: 445-455
- Molecular events in axonal regeneration.in: Nicholls J.G. Repair and Regeneration of the Nervous System. Springer-Verlag, Berlin1982: 71-89
- ACTH, cyclic nucleotides, and brain protein phosphorylation in vitro.Neurochem. Res. 1976; 1: 669-677
Article info
Publication history
Accepted:
March 12,
1984
Received:
March 5,
1984
Footnotes
☆This work was supported in part by the Princess Beatrixfonds.
Identification
Copyright
© 1984 Published by Elsevier Inc.
