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Research Article| Volume 64, ISSUE 3, P325-331, June 1984

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Elevation of neuropeptide Y (NPY) in substantia innominata in Alzheimer's type dementia

DOI:https://doi.org/10.1016/0022-510X(84)90180-1
Elevation of neuropeptide Y (NPY) in substantia innominata in Alzheimer's type dementia
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      Abstract

      Concentrations of neuropeptide Y (NPY) have been determined in 12 areas of control brains and compared to those found in brains from patients with Alzheimer's type dementia (ATD). The distribution of NPY in the control brains was compared with those reported previously. Highest concentrations were identified in the subcortical structures, in particular, nucleus accumbens (203 ± 21.7 pmol/g), amygdala (136.7 ± 15.8 pmol/g), and substantia innominata (109.0 ± 12.6 pmol/g). A significant elevation in NPY concentrations was identified in the region of the substantia innominata of Alzheimer brains (controls: 109.0 ± 12.6 pmol/g, ATD: 206 ± 28.2 pmol/g, P < 0.001). This change in NPY concentration was similar to the increase in somatostatin concentration in this region of ATD brain. In contrast, although cortical concentrations of somatostatin were reduced in ATD, no change was found in the concentrations of NPY in the 4 regions of cerebral cortex and the remaining subcortical areas examined.

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      Article info

      Publication history

      Accepted: March 2, 1984
      Received in revised form: March 1, 1984
      Received: December 10, 1983

      Footnotes

      ☆JMA and INF are in receipt of Wellcome Trust Training Fellowships.

      Identification

      DOI: https://doi.org/10.1016/0022-510X(84)90180-1

      Copyright

      © 1984 Published by Elsevier Inc.

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