This paper is only available as a PDF. To read, Please Download here.
Abstract
Using an electron histochemical technique, we have observed the binding of a d-galactose-specific lectin to the muscle cell plasma membrane in muscle biopsies taken
from patients with various neuromuscular disorders. In spinal muscular atrophy, the
only neurogenic disease studied, the plasma membrane stained as in normal muscle.
However, in the myopathies Becker and limb-girdle muscular dystrophy and in the polymyositis
there was a reduction in both the occurrence and the intensity of staining of the
plasma membrane. Reduced lectin binding by the plasma membrane probably reflects secondary
changes in the composition of glycoproteins and/or glycolipids in the membrane and
seems to be common to all these myopathies to varying degrees.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Ultrastructural visualization of cellular carbohydrate compounds by means of Concanavalin A.Exp. Cell Res. 1971; 64: 232-236
- Duchenne dystrophy — Focal alterations in the distribution of concanavalin A binding sites at the muscle cell surface.Ann. Neurol. 1978; 4: 117-123
- Application of lectin cytochemistry to the study of human neuromuscular disease.Muscle and Nerve. 1980; 3: 28-35
- Altered binding of Ricinus Communis I lectin by muscle membranes in Duchenne muscular dystrophy.J. Neurol. Sci. 1984; 63: 129-142
- Muscle Disorders in Childhood.Saunders, London1978
- Cytochemical studies of lectin binding by diseased human muscle.J. Neurol. Sci. 1982; 55: 147-159
- Comparison of fixation and penetration enhancement techniques for use in ultrastructural immunocytochemistry.J. Histochem. Cytochem. 1983; 31: 285-292
- Cell mediated immunity in polymyositis.Arch. Neurol. (Chic.). 1974; 31: 192-196
- Membrane abnormalities in Duchenne muscular dystrophy.J. Neurol. Sci. 1983; 58: 159-179
- Biochemistry of muscle membranes in Duchenne muscular dystrophy.Muscle and Nerve. 1980; 3: 3-20
- Quantitative freeze-fracture electron miscroscopy of dystrophic muscle membranes.J. Neurol. Sci. 1982; 57: 161-190
Article info
Publication history
Accepted:
February 21,
1984
Received in revised form:
February 21,
1984
Received:
January 17,
1984
Footnotes
☆This work was supported by the Wellcome Trust and the Muscular Dystrophy Group of Great Britain.
Identification
Copyright
© 1984 Published by Elsevier Inc.
