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Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of anti-GalC serum. Demyelination appears to result from primary damage to oligodendrocytes.
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Accepted: February 7, 1984
Received in revised form: February 7, 1984
Received: August 29, 1983
☆This project was supported by grants from the NIH (NS-11037, NS-08075), the Kroc Foundation, the National Multiple Sclerosis Society, and a research fellowship grant from the Heed Ophthalmic Foundation.
© 1984 Published by Elsevier Inc.