Research Article| Volume 64, ISSUE 1, P79-87, April 1984

Severe muscular dystrophy in girls

  • David Gardner-Medwin
    Correspondence to: Dr. D. Gardner-Medwin, Regional Neurological Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, Great Britain.
    Department of Neurology, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE Great Britain
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  • Heather M. Johnston
    Department of Child Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE Great Britain
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  • Author Footnotes
    ∗ Present address: Department of Paediatric Neurology, The Prince of Wales Children's Hospital, Randwick, N.S.W., Australia.
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      Twelve girls and 2 boys with severe but not congenital muscular dystrophy were found in a national survey. An autosomal recessive gene is likely to account for most if not all of these cases. The condition differs slightly from X-linked Duchenne muscular dystrophy in showing prominent early toe-walking, a milder course, relatively more weakness of the deltoid muscles, normal intelligence, a normal ECG and a more focal pattern of muscle pathology.


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