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Research Article| Volume 64, ISSUE 1, P11-20, April 1984

DNA damage and chronic neuronal degenerations

DOI:https://doi.org/10.1016/0022-510X(84)90051-0
DNA damage and chronic neuronal degenerations
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      Abstract

      DNA plays an essential role not only in dividing cells, but also in postmitotic cells such as neurons. Accumulated damage to the nuclear DNA will result in damage to neuronal metabolism. There is suggestive evidence of altered DNA in ALS, Alzheimer's and Parkinson's diseases, and of deficiency of DNA repair mechanisms in these age-related neuronal degenerations and in Huntington's disease. We suggest that these DNA abnormalities are more likely to be the cause of the diseases, rather than an effect of the disease process.

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      Article info

      Footnotes

      ☆This work was supported by grants from the ALS Society of America and the American Parkinson's Disease Association.

      Identification

      DOI: https://doi.org/10.1016/0022-510X(84)90051-0

      Copyright

      © 1984 Published by Elsevier Inc.

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