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A study of 206 patients with multiple sclerosis in the north-east of England and their families shows no evidence of monogenic involvement in the disorder. Much more likely is a multifactorial etiology in which the genetic component is polygenic. On this model the heritability is calculated at 52.1% or 40.9% if age variation in incidence is allowed for. The genetic component is present but no more than moderate in extent.
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Accepted: November 12, 1981
Received: September 14, 1981
☆This study was supported financially by the Multiple Sclerosis Society.
© 1982 Published by Elsevier Inc.