Research Article| Volume 54, ISSUE 2, P287-293, May 1982

The genetic contribution to multiple sclerosis

Evidence from North-East England
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      A study of 206 patients with multiple sclerosis in the north-east of England and their families shows no evidence of monogenic involvement in the disorder. Much more likely is a multifactorial etiology in which the genetic component is polygenic. On this model the heritability is calculated at 52.1% or 40.9% if age variation in incidence is allowed for. The genetic component is present but no more than moderate in extent.
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