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Abstract
A study of 206 patients with multiple sclerosis in the north-east of England and their
families shows no evidence of monogenic involvement in the disorder. Much more likely
is a multifactorial etiology in which the genetic component is polygenic. On this
model the heritability is calculated at 52.1% or 40.9% if age variation in incidence
is allowed for. The genetic component is present but no more than moderate in extent.
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References
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- The inheritance of liability to disease with variable age of onset, with particular reference to diabetes mellitus.Ann. hum. Genet. 1967; 31: 1-20
- McAlpine D. Lumsden C.E. Acheson E.D. Multiple Sclerosis. 2nd edition. Livingstone, London1972
- The etiology of multiple sclerosis — Temporal-spatial clustering indicating two environmental exposures before onset.J. Epidemiol. Comm. Hlth. 1980; 34: 265-270
- Genetic analysis of multiple sclerosis in Orkney.J. Epidemiol. Comm. Hlth. 1979; 33: 229-235
- Familial and conjugal multiple sclerosis.Brain. 1963; 86: 315-332
Article info
Publication history
Accepted:
November 12,
1981
Received:
September 14,
1981
Footnotes
☆This study was supported financially by the Multiple Sclerosis Society.
Identification
Copyright
© 1982 Published by Elsevier Inc.
