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Abstract
The presence of complement-fixing antibrain antibodies is a distinctive feature of
multiple sclerosis (MS). In a longitudinal study of 35 MS patients antibrain antibody
titres in serum were followed for up to 5 years; in 18 of them also CSF titres were
determined. No consistent correlations between antibrain antibody titres and clinical
events were found. Thus, MS relapses are not caused by a general increase in antibrain
antibody titres, and conversely the relapses did not cause a boosting of antibrain
antibodies. Significant variations in the local plaque environment are, however, not
ruled out by the present results.
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References
- Multiple sclerosis — A quantitative and qualitative study of immunoglobulin-containing cells in the central nervous system.Neuropath. appl. Neurobiol. 1980; 6: 9-21
- Antibody-dependent lymphocyte cytotoxicity against basic protein of myelin in multiple sclerosis.J. neurol. Sci. 1980; 46: 187-197
- Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains.Nature (Lond.). 1980; 287: 335-337
- Studies on disseminated sclerosis.Acta med. scand. 1949; 133: 1-214
- Loss of suppressor T cells in active multiple sclerosis.N. Engl. J. Med. 1980; 303: 125-129
- A longitudinal study on antibodies to measles and rubella viruses in patients with multiple sclerosis — A preliminary report.Acta neurol. scand. 1976; 54: 366-370
- Multiple specificities of antibrain antibodies in multiple sclerosis and chronic myelopathy.J. neurol. Sci. 1978; 38: 357-382
- Intrathecal and extrathecal production of antibrain antibodies in multiple sclerosis.J. neurol. Sci. 1980; 48: 1-8
- Antibrain antibodies in multiple sclerosis — Relation to clinical variables.J. neurol. Sci. 1982; 54: 239-261
- Immunoglobulin characterization by bacterial absorption of antibrain antibodies in multiple sclerosis.Europ. Neurol. 1981; 20: 374-379
- Infection and immunization in multiple sclerosis.Ann. N.Y. Acad. Sci. 1965; 122: 457-468
Article info
Publication history
Accepted:
November 11,
1981
Received in revised form:
November 9,
1981
Received:
June 11,
1981
Footnotes
☆This study was supported by grants from the Medical Faculty, University of Lund, Sweden, the Greta and Johan Kock Foundation, the Alfred Österlund Foundation, and the Elsa Schmitz Foundation.
Identification
Copyright
© 1982 Published by Elsevier Inc.
