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The presence of complement-fixing antibrain antibodies is a distinctive feature of multiple sclerosis (MS). In a longitudinal study of 35 MS patients antibrain antibody titres in serum were followed for up to 5 years; in 18 of them also CSF titres were determined. No consistent correlations between antibrain antibody titres and clinical events were found. Thus, MS relapses are not caused by a general increase in antibrain antibody titres, and conversely the relapses did not cause a boosting of antibrain antibodies. Significant variations in the local plaque environment are, however, not ruled out by the present results.
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Accepted: November 11, 1981
Received in revised form: November 9, 1981
Received: June 11, 1981
☆This study was supported by grants from the Medical Faculty, University of Lund, Sweden, the Greta and Johan Kock Foundation, the Alfred Österlund Foundation, and the Elsa Schmitz Foundation.
© 1982 Published by Elsevier Inc.